TY - JOUR
T1 - Relationship between dementia and ankylosing spondylitis
T2 - A nationwide, population-based, retrospective longitudinal cohort study
AU - Jang, Hae Dong
AU - Park, Jin Sung
AU - Kim, Dae Woong
AU - Han, Kyungdo
AU - Shin, Byung Joon
AU - Lee, Jae Chul
AU - Choi, Sung Woo
AU - Suh, Seung Woo
AU - Yang, Jae Hyuk
AU - Park, Si Young
AU - Cho, Whi Je
AU - Hong, Jae Young
N1 - Funding Information:
The Manuscript submitted does not contain information about medical device(s)/drug (s). This work was supported by the Soonchunhyang University Research Fund. No relevant financial activities outside the submitted work. The authors would like to thank the South Korean National Health Insurance Service for providing the K-NHIS data and Sukyung Kang, T.D., for assisting with the preparation and revision of the paper.
Publisher Copyright:
© 2019 Jang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2019/1
Y1 - 2019/1
N2 - Among a variety of comorbidities of ankylosing spondylitis (AS), the association between dementia and AS by using an extensive dataset from the Korean National Health Insurance System was evaluated in this study. We extracted 15,547 newly diagnosed AS subjects among the entire Korean population and excluded wash-out patients (n = 162) and patients that were inappropriate for cohort match (n = 1192). Finally, 14,193 subjects were chosen as the AS group, and through 1:5 age- and sex-stratified matching, 70,965 subjects were chosen as the control group. We evaluated patient demographics, household incomes, and comorbidities, including hypertension, diabetes, and dyslipidemia. The prevalence of overall dementia (1.37%) and Alzheimer’s dementia (AD) (0.99%) in the AS group was significantly higher than in the control group (0.87% and 0.63%), respectively. The adjusted hazard ratio of the AS group for overall dementia (1.758) and AD (1.782) showed statistical significance also. On the other hand, the prevalence of vascular dementia did not differ significantly between the two groups. Subgroup analyses revealed the following risk factors for dementia in the AS group: male gender, greater than 65 years in age, fair income (household income greater than 20% of the median), urban residency, no diabetes, and no hypertension. From the nationwide, population-based, retrospective, longitudinal cohort study, AS patients showed a significantly higher prevalence of overall dementia and Alzheimer’s dementia. Comprehensive patient assessment using our subgroup analysis could help to prevent dementia in patients suffering from AS.
AB - Among a variety of comorbidities of ankylosing spondylitis (AS), the association between dementia and AS by using an extensive dataset from the Korean National Health Insurance System was evaluated in this study. We extracted 15,547 newly diagnosed AS subjects among the entire Korean population and excluded wash-out patients (n = 162) and patients that were inappropriate for cohort match (n = 1192). Finally, 14,193 subjects were chosen as the AS group, and through 1:5 age- and sex-stratified matching, 70,965 subjects were chosen as the control group. We evaluated patient demographics, household incomes, and comorbidities, including hypertension, diabetes, and dyslipidemia. The prevalence of overall dementia (1.37%) and Alzheimer’s dementia (AD) (0.99%) in the AS group was significantly higher than in the control group (0.87% and 0.63%), respectively. The adjusted hazard ratio of the AS group for overall dementia (1.758) and AD (1.782) showed statistical significance also. On the other hand, the prevalence of vascular dementia did not differ significantly between the two groups. Subgroup analyses revealed the following risk factors for dementia in the AS group: male gender, greater than 65 years in age, fair income (household income greater than 20% of the median), urban residency, no diabetes, and no hypertension. From the nationwide, population-based, retrospective, longitudinal cohort study, AS patients showed a significantly higher prevalence of overall dementia and Alzheimer’s dementia. Comprehensive patient assessment using our subgroup analysis could help to prevent dementia in patients suffering from AS.
UR - http://www.scopus.com/inward/record.url?scp=85060887647&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0210335
DO - 10.1371/journal.pone.0210335
M3 - Article
C2 - 30703142
AN - SCOPUS:85060887647
SN - 1932-6203
VL - 14
JO - PLoS One
JF - PLoS One
IS - 1
M1 - e0210335
ER -
