TY - JOUR
T1 - Relationship between pulmonary hypertension, peripheral vascular calcification, and major cardiovascular events in dialysis patients
AU - Kim, Sun Chul
AU - Chang, Hyo Jung
AU - Kim, Myung Gyu
AU - Jo, Sang Kyung
AU - Cho, Won Yong
AU - Kim, Hyoung Kyu
N1 - Funding Information:
This study was supported by a grant from Korea University .
Publisher Copyright:
© 2015. The Korean Society of Nephrology. Published by Elsevier. All rights reserved.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Background Pulmonary hypertension (PHT) is a recently recognized complication of chronic kidney disease. In this study, we investigated the association between PHT, peripheral vascular calcifications (VCs), and major cardiovascular events. Methods In this retrospective study, we included 172 end-stage renal disease (ESRD) patients undergoing dialysis [hemodialysis (HD)=84, peritoneal dialysis=88]. PHT was defined as an estimated pulmonary artery systolic pressure>37 mmHg using echocardiography. The Simple Vascular Calcification Score (SVCS) was measured using plain radiographic films of the hands and pelvis. Results The prevalence of PHT was significantly higher in HD patients (51.2% vs. 22.7%). Dialysis patients with PHT had a significantly higher prevalence of severe VCs (SVCS≥ 3). In multivariate analysis, the presence of severe VCs [odds ratio (OR), 2.68], mitral valve disease (OR, 7.79), HD (OR, 3.35), and larger left atrial diameter (OR, 11.39) were independent risk factors for PHT. In addition to the presence of anemia, severe VCs, or older age, the presence of PHT was an independent predictor of major cardiovascular events in ESRD patients. Conclusion The prevalence of PHT was higher in HD patients and was associated with higher rates of major cardiovascular events. Severe VCs are thought to be an independent risk factor for predicting PHT in ESRD patients. Therefore, in dialysis patients with PHT, careful attention should be paid to the presence of VCs and the occurrence of major cardiovascular events.
AB - Background Pulmonary hypertension (PHT) is a recently recognized complication of chronic kidney disease. In this study, we investigated the association between PHT, peripheral vascular calcifications (VCs), and major cardiovascular events. Methods In this retrospective study, we included 172 end-stage renal disease (ESRD) patients undergoing dialysis [hemodialysis (HD)=84, peritoneal dialysis=88]. PHT was defined as an estimated pulmonary artery systolic pressure>37 mmHg using echocardiography. The Simple Vascular Calcification Score (SVCS) was measured using plain radiographic films of the hands and pelvis. Results The prevalence of PHT was significantly higher in HD patients (51.2% vs. 22.7%). Dialysis patients with PHT had a significantly higher prevalence of severe VCs (SVCS≥ 3). In multivariate analysis, the presence of severe VCs [odds ratio (OR), 2.68], mitral valve disease (OR, 7.79), HD (OR, 3.35), and larger left atrial diameter (OR, 11.39) were independent risk factors for PHT. In addition to the presence of anemia, severe VCs, or older age, the presence of PHT was an independent predictor of major cardiovascular events in ESRD patients. Conclusion The prevalence of PHT was higher in HD patients and was associated with higher rates of major cardiovascular events. Severe VCs are thought to be an independent risk factor for predicting PHT in ESRD patients. Therefore, in dialysis patients with PHT, careful attention should be paid to the presence of VCs and the occurrence of major cardiovascular events.
KW - Cardiovascular disease
KW - Dialysis
KW - Pulmonary hypertension
UR - http://www.scopus.com/inward/record.url?scp=84926219421&partnerID=8YFLogxK
U2 - 10.1016/j.krcp.2015.01.003
DO - 10.1016/j.krcp.2015.01.003
M3 - Article
AN - SCOPUS:84926219421
SN - 2211-9132
VL - 34
SP - 28
EP - 34
JO - Kidney Research and Clinical Practice
JF - Kidney Research and Clinical Practice
IS - 1
ER -