Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6

Hye Soon Park; Jung Yul Park; Rina Yu

doi:10.1016/j.diabres.2004.11.007

Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6

Hye Soon Park, Jung Yul Park, Rina Yu

Research output: Contribution to journal › Article › peer-review

759 Citations (Scopus)

Abstract

Objective: To investigate the relationship between serum concentrations of the cytokines C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and interleukin (IL)-6, and obesity and visceral adiposity. Methods: A cross-sectional study of 100 Korean adults free from pre-existing inflammatory disease or cancer was performed. Body mass index (BMI), waist circumference, and serum concentrations of CRP, TNF-α and IL-6 were measured. In 46 obese subjects, fat mass was assessed by bioimpedance analysis and abdominal fat distribution was determined by computerized tomography scan. Results: Overall, serum concentrations of CRP, TNF-α and IL-6 were significantly correlated with weight, BMI, waist circumference, hip circumference, and waist-hip ratio. In obese subjects, CRP and IL-6 were significantly correlated with BMI, waist circumference and visceral adipose tissue. Multiple regression analysis showed that CRP was significantly associated with BMI, whereas IL-6 was significantly related with visceral adiposity in obese subjects. Conclusions: The positive associations of obesity and visceral adiposity with elevated cytokine levels suggest the importance of reducing obesity and visceral adiposity to prevent elevations in cytokine levels.

Original language	English
Pages (from-to)	29-35
Number of pages	7
Journal	Diabetes Research and Clinical Practice
Volume	69
Issue number	1
DOIs	https://doi.org/10.1016/j.diabres.2004.11.007
Publication status	Published - 2005 Jul

Bibliographical note

Funding Information:
This study was supported by a Grant from the Asan Institute for Life Science 2002-106 and a SRC fund to IRC at the University of Ulsan from the KOSEF and the Korean Ministry Science and Technology.

Keywords

CRP
IL-6
Obesity
TNF-α
Visceral adiposity

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diabres.2004.11.007

Cite this

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title = "Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6",

abstract = "Objective: To investigate the relationship between serum concentrations of the cytokines C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and interleukin (IL)-6, and obesity and visceral adiposity. Methods: A cross-sectional study of 100 Korean adults free from pre-existing inflammatory disease or cancer was performed. Body mass index (BMI), waist circumference, and serum concentrations of CRP, TNF-α and IL-6 were measured. In 46 obese subjects, fat mass was assessed by bioimpedance analysis and abdominal fat distribution was determined by computerized tomography scan. Results: Overall, serum concentrations of CRP, TNF-α and IL-6 were significantly correlated with weight, BMI, waist circumference, hip circumference, and waist-hip ratio. In obese subjects, CRP and IL-6 were significantly correlated with BMI, waist circumference and visceral adipose tissue. Multiple regression analysis showed that CRP was significantly associated with BMI, whereas IL-6 was significantly related with visceral adiposity in obese subjects. Conclusions: The positive associations of obesity and visceral adiposity with elevated cytokine levels suggest the importance of reducing obesity and visceral adiposity to prevent elevations in cytokine levels.",

keywords = "CRP, IL-6, Obesity, TNF-α, Visceral adiposity",

author = "Park, {Hye Soon} and Park, {Jung Yul} and Rina Yu",

note = "Funding Information: This study was supported by a Grant from the Asan Institute for Life Science 2002-106 and a SRC fund to IRC at the University of Ulsan from the KOSEF and the Korean Ministry Science and Technology.",

year = "2005",

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doi = "10.1016/j.diabres.2004.11.007",

language = "English",

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AU - Park, Hye Soon

AU - Park, Jung Yul

AU - Yu, Rina

N1 - Funding Information: This study was supported by a Grant from the Asan Institute for Life Science 2002-106 and a SRC fund to IRC at the University of Ulsan from the KOSEF and the Korean Ministry Science and Technology.

PY - 2005/7

Y1 - 2005/7

N2 - Objective: To investigate the relationship between serum concentrations of the cytokines C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and interleukin (IL)-6, and obesity and visceral adiposity. Methods: A cross-sectional study of 100 Korean adults free from pre-existing inflammatory disease or cancer was performed. Body mass index (BMI), waist circumference, and serum concentrations of CRP, TNF-α and IL-6 were measured. In 46 obese subjects, fat mass was assessed by bioimpedance analysis and abdominal fat distribution was determined by computerized tomography scan. Results: Overall, serum concentrations of CRP, TNF-α and IL-6 were significantly correlated with weight, BMI, waist circumference, hip circumference, and waist-hip ratio. In obese subjects, CRP and IL-6 were significantly correlated with BMI, waist circumference and visceral adipose tissue. Multiple regression analysis showed that CRP was significantly associated with BMI, whereas IL-6 was significantly related with visceral adiposity in obese subjects. Conclusions: The positive associations of obesity and visceral adiposity with elevated cytokine levels suggest the importance of reducing obesity and visceral adiposity to prevent elevations in cytokine levels.

AB - Objective: To investigate the relationship between serum concentrations of the cytokines C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and interleukin (IL)-6, and obesity and visceral adiposity. Methods: A cross-sectional study of 100 Korean adults free from pre-existing inflammatory disease or cancer was performed. Body mass index (BMI), waist circumference, and serum concentrations of CRP, TNF-α and IL-6 were measured. In 46 obese subjects, fat mass was assessed by bioimpedance analysis and abdominal fat distribution was determined by computerized tomography scan. Results: Overall, serum concentrations of CRP, TNF-α and IL-6 were significantly correlated with weight, BMI, waist circumference, hip circumference, and waist-hip ratio. In obese subjects, CRP and IL-6 were significantly correlated with BMI, waist circumference and visceral adipose tissue. Multiple regression analysis showed that CRP was significantly associated with BMI, whereas IL-6 was significantly related with visceral adiposity in obese subjects. Conclusions: The positive associations of obesity and visceral adiposity with elevated cytokine levels suggest the importance of reducing obesity and visceral adiposity to prevent elevations in cytokine levels.

KW - CRP

KW - IL-6

KW - Obesity

KW - TNF-α

KW - Visceral adiposity

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Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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