Relative efficacy and safety of apremilast, secukinumab, and ustekinumab for the treatment of psoriatic arthritis

G. G. Song, Y. H. Lee

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)

    Abstract

    Objective: To assess the relative efficacy and safety of apremilast, secukinumab, and ustekinumab at different doses in patients with active psoriatic arthritis (PsA). Method: A Bayesian network meta-analysis was conducted, which included randomized controlled trials (RCTs) that examined the efficacy and safety of apremilast 20 mg, apremilast 30 mg, secukinumab 75 mg, secukinumab 150 mg, secukinumab 300 mg, ustekinumab 45 mg, and ustekinumab 90 mg compared with placebo. Results: Of the RCTs 8 comprising 3289 patients met the inclusion criteria. The American College of Rheumatology (ACR) 20 response rate was significantly higher in the secukinumab 300 mg group than in the placebo group (odds ratio OR, 7.55; 95% confidence interval CI, 3.18–17.63). Secukinumab 150 mg, secukinumab 75 mg, ustekinumab 90 mg, apremilast 30 mg, apremilast 20 mg, and ustekinumab 45 mg were also more efficacious than placebo. There were no significant differences in the efficacy between the interventions. A dose-response relationship among the same drug groups was observed. The number of serious adverse events was not significantly different among the apremilast, secukinumab, ustekinumab, and placebo groups. Conclusion: All drug treatments were more efficacious than placebo; however, there were no significant differences in the efficacy and safety between the drugs at the different doses.

    Original languageEnglish
    Pages (from-to)613-620
    Number of pages8
    JournalZeitschrift fur Rheumatologie
    Volume77
    Issue number7
    DOIs
    Publication statusPublished - 2018 Sept 1

    Bibliographical note

    Publisher Copyright:
    © 2017, Springer Medizin Verlag GmbH.

    Keywords

    • Apremilast
    • Psoriatic arthritis
    • Secukinumab
    • Ustekinumab

    ASJC Scopus subject areas

    • Rheumatology

    Fingerprint

    Dive into the research topics of 'Relative efficacy and safety of apremilast, secukinumab, and ustekinumab for the treatment of psoriatic arthritis'. Together they form a unique fingerprint.

    Cite this