Release profile of a model protein drug depending on the stability of microspheres based on polyelectrolyte complex

Sungwon Kim; Yun Sik Nam; Yeon Jin Min; Jong Ho Kim; Kwangmeyong Kim; Kui Won Choi; Insup Noh; Ick Chan Kwon

doi:10.4028/0-87849-436-7.505

Release profile of a model protein drug depending on the stability of microspheres based on polyelectrolyte complex

Sungwon Kim, Yun Sik Nam, Yeon Jin Min, Jong Ho Kim, Kwangmeyong Kim, Kui Won Choi, Insup Noh, Ick Chan Kwon

Research output: Contribution to journal › Article › peer-review

Abstract

Stability and disintegration of natural polyelectrolyte complex microspheres for protein drugs delivery have been extensively investigated because of their great influence on the drug release patterns. In this study, we tested stability of microspheres with alginate (Alg) core layered by either chitosan (Chi) or glycol chitosan (GChi) by examining release profiles of fluorophorelabeled bovine serum albumin (BSA) and lysozyme (Lys) from the microspheres. While GChi shell was disintegrated quickly, Chi-shell microspheres showed good stability in PBS. Disintegration of the coated layer induced the core material instable. The results indicated that while the charges of the shell material provided additional diffusion barrier against the protein release, the key factor to hold the proteins inside the microspheres was the integrity of the outer coating layer.

Original language	English
Pages (from-to)	505-508
Number of pages	4
Journal	Key Engineering Materials
Volume	342-343
DOIs	https://doi.org/10.4028/0-87849-436-7.505
Publication status	Published - 2007

Keywords

Alginate
Chitosan
Controlled release
Polyelectrolyte complex
Protein drug

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.4028/0-87849-436-7.505

Cite this

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title = "Release profile of a model protein drug depending on the stability of microspheres based on polyelectrolyte complex",

abstract = "Stability and disintegration of natural polyelectrolyte complex microspheres for protein drugs delivery have been extensively investigated because of their great influence on the drug release patterns. In this study, we tested stability of microspheres with alginate (Alg) core layered by either chitosan (Chi) or glycol chitosan (GChi) by examining release profiles of fluorophorelabeled bovine serum albumin (BSA) and lysozyme (Lys) from the microspheres. While GChi shell was disintegrated quickly, Chi-shell microspheres showed good stability in PBS. Disintegration of the coated layer induced the core material instable. The results indicated that while the charges of the shell material provided additional diffusion barrier against the protein release, the key factor to hold the proteins inside the microspheres was the integrity of the outer coating layer.",

keywords = "Alginate, Chitosan, Controlled release, Polyelectrolyte complex, Protein drug",

author = "Sungwon Kim and Nam, {Yun Sik} and Min, {Yeon Jin} and Kim, {Jong Ho} and Kwangmeyong Kim and Choi, {Kui Won} and Insup Noh and Kwon, {Ick Chan}",

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doi = "10.4028/0-87849-436-7.505",

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journal = "Key Engineering Materials",

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T1 - Release profile of a model protein drug depending on the stability of microspheres based on polyelectrolyte complex

AU - Kim, Sungwon

AU - Nam, Yun Sik

AU - Min, Yeon Jin

AU - Kim, Jong Ho

AU - Kim, Kwangmeyong

AU - Choi, Kui Won

AU - Noh, Insup

AU - Kwon, Ick Chan

PY - 2007

Y1 - 2007

N2 - Stability and disintegration of natural polyelectrolyte complex microspheres for protein drugs delivery have been extensively investigated because of their great influence on the drug release patterns. In this study, we tested stability of microspheres with alginate (Alg) core layered by either chitosan (Chi) or glycol chitosan (GChi) by examining release profiles of fluorophorelabeled bovine serum albumin (BSA) and lysozyme (Lys) from the microspheres. While GChi shell was disintegrated quickly, Chi-shell microspheres showed good stability in PBS. Disintegration of the coated layer induced the core material instable. The results indicated that while the charges of the shell material provided additional diffusion barrier against the protein release, the key factor to hold the proteins inside the microspheres was the integrity of the outer coating layer.

AB - Stability and disintegration of natural polyelectrolyte complex microspheres for protein drugs delivery have been extensively investigated because of their great influence on the drug release patterns. In this study, we tested stability of microspheres with alginate (Alg) core layered by either chitosan (Chi) or glycol chitosan (GChi) by examining release profiles of fluorophorelabeled bovine serum albumin (BSA) and lysozyme (Lys) from the microspheres. While GChi shell was disintegrated quickly, Chi-shell microspheres showed good stability in PBS. Disintegration of the coated layer induced the core material instable. The results indicated that while the charges of the shell material provided additional diffusion barrier against the protein release, the key factor to hold the proteins inside the microspheres was the integrity of the outer coating layer.

KW - Alginate

KW - Chitosan

KW - Controlled release

KW - Polyelectrolyte complex

KW - Protein drug

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Release profile of a model protein drug depending on the stability of microspheres based on polyelectrolyte complex

Abstract

Keywords

ASJC Scopus subject areas

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