Research Update: Nanoscale surface potential analysis of MoS2 field-effect transistors for biomolecular detection using Kelvin probe force microscopy

Min Hyung Kim; Heekyeong Park; Hyungbeen Lee; Kihwan Nam; Seokhwan Jeong; Inturu Omkaram; Dae Sung Yoon; Sei Young Lee; Sunkook Kim; Sang Woo Lee

doi:10.1063/1.4964488

Research Update: Nanoscale surface potential analysis of MoS₂ field-effect transistors for biomolecular detection using Kelvin probe force microscopy

Min Hyung Kim, Heekyeong Park, Hyungbeen Lee, Kihwan Nam, Seokhwan Jeong, Inturu Omkaram, Dae Sung Yoon, Sei Young Lee, Sunkook Kim, Sang Woo Lee

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

We used high-resolution Kelvin probe force microscopy (KPFM) to investigate the immobilization of a prostate specific antigen (PSA) antibody by measuring the surface potential (SP) on a MoS₂ surface over an extensive concentration range (1 pg/ml-100 μg/ml). After PSA antibody immobilization, we demonstrated that the SP on the MoS₂ surface characterized by KPFM strongly correlated to the electrical signal of a MoS₂ bioFET. This demonstration can not only be used to optimize the immobilization conditions for captured molecules, but can also be applied as a diagnostic tool to complement the electrical detection of a MoS₂ FET biosensor.

Original language	English
Article number	100701
Journal	APL Materials
Volume	4
Issue number	10
DOIs	https://doi.org/10.1063/1.4964488
Publication status	Published - 2016 Oct 1

Bibliographical note

Publisher Copyright:
© 2016 Author(s).

ASJC Scopus subject areas

General Materials Science
General Engineering

Access to Document

10.1063/1.4964488

Cite this

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title = "Research Update: Nanoscale surface potential analysis of MoS2 field-effect transistors for biomolecular detection using Kelvin probe force microscopy",

abstract = "We used high-resolution Kelvin probe force microscopy (KPFM) to investigate the immobilization of a prostate specific antigen (PSA) antibody by measuring the surface potential (SP) on a MoS2 surface over an extensive concentration range (1 pg/ml-100 μg/ml). After PSA antibody immobilization, we demonstrated that the SP on the MoS2 surface characterized by KPFM strongly correlated to the electrical signal of a MoS2 bioFET. This demonstration can not only be used to optimize the immobilization conditions for captured molecules, but can also be applied as a diagnostic tool to complement the electrical detection of a MoS2 FET biosensor.",

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AU - Lee, Hyungbeen

AU - Nam, Kihwan

AU - Jeong, Seokhwan

AU - Omkaram, Inturu

AU - Yoon, Dae Sung

AU - Lee, Sei Young

AU - Kim, Sunkook

AU - Lee, Sang Woo

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