Abstract
Objective: To report a 4-case series in which amisulpride-induced symptomatic hyperprolactinemia was resolved by switching to aripiprazole. Case Reports: Four female patients developed symptomatic hyperprolactinemia such as amenorrhea and/or galactorrhea with elevated serum prolactin levels (113.7-230.0 ng/mL) after taking amisulpride (200-800 mg/day). To resolve the problem of symptomatic hyperprolactinemia, reducing the dosage of amisulpride was first tried, however this approach turned out to have no effect. Subsequently, all 4 patients were switched from amisulpride to aripiprazole (10-20 mg/day), upon which their regular menstrual cycles returned and galactorrhea improved, with the normalization of their serum prolactin levels (6.5-15.0 ng/mL) within 4 weeks after switching. Conclusion: Switching to aripiprazole, a partial dopamine agonist, is an effective strategy for the resolution of antipsychotic-induced hyperprolactinemia and associated adverse effects.
Original language | English |
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Pages (from-to) | 102-106 |
Number of pages | 5 |
Journal | Psychiatry Investigation |
Volume | 3 |
Issue number | 1 |
Publication status | Published - 2006 Feb |
Keywords
- Amenorrhea
- Amisulpride
- Aripiprazole
- Galactorrhea
- Prolactin
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry