Resolving m6A epitranscriptome with stoichiometry

Ki Jun Yoon, Yoon Ki Kim

Research output: Contribution to journalShort surveypeer-review


A recent study by Hu et al. describes N6-methyladenosine (m6A)-selective allyl chemical labeling and sequencing (m6A-SAC-seq), which allows for quantitative, stoichiometric, and positional analyses of m6A at single-nucleotide resolution across the whole transcriptome level. Information on the m6A stoichiometry will provide additional layers of gene regulatory pathways mediated by m6A modification during diverse molecular, cellular, and physiological events.

Original languageEnglish
Pages (from-to)1099-1100
Number of pages2
JournalTrends in Genetics
Issue number11
Publication statusPublished - 2022 Nov

Bibliographical note

Funding Information:
This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIP; NRF-2015R1A3A2033665 and NRF-2018R1A5A1024261 to Y.K.K; and 2019R1C1C1006600 and 2020M3A9E4039670 to K-J.Y.).

Publisher Copyright:
© 2022 Elsevier Ltd


  • chemical-assisted sequencing
  • mA modification
  • mA-SAC-seq
  • quantitative analysis
  • stoichiometry

ASJC Scopus subject areas

  • Genetics


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