Resolving m6A epitranscriptome with stoichiometry

Ki Jun Yoon; Yoon Ki Kim

doi:10.1016/j.tig.2022.06.009

Resolving m⁶A epitranscriptome with stoichiometry

Ki Jun Yoon, Yoon Ki Kim

Research output: Contribution to journal › Short survey › peer-review

Abstract

A recent study by Hu et al. describes N⁶-methyladenosine (m⁶A)-selective allyl chemical labeling and sequencing (m⁶A-SAC-seq), which allows for quantitative, stoichiometric, and positional analyses of m⁶A at single-nucleotide resolution across the whole transcriptome level. Information on the m⁶A stoichiometry will provide additional layers of gene regulatory pathways mediated by m⁶A modification during diverse molecular, cellular, and physiological events.

Original language	English
Pages (from-to)	1099-1100
Number of pages	2
Journal	Trends in Genetics
Volume	38
Issue number	11
DOIs	https://doi.org/10.1016/j.tig.2022.06.009
Publication status	Published - 2022 Nov

Bibliographical note

Funding Information:
This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIP; NRF-2015R1A3A2033665 and NRF-2018R1A5A1024261 to Y.K.K; and 2019R1C1C1006600 and 2020M3A9E4039670 to K-J.Y.).

Publisher Copyright:
© 2022 Elsevier Ltd

Keywords

chemical-assisted sequencing
mA modification
mA-SAC-seq
quantitative analysis
stoichiometry

ASJC Scopus subject areas

Genetics

Access to Document

10.1016/j.tig.2022.06.009

Cite this

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title = "Resolving m6A epitranscriptome with stoichiometry",

abstract = "A recent study by Hu et al. describes N6-methyladenosine (m6A)-selective allyl chemical labeling and sequencing (m6A-SAC-seq), which allows for quantitative, stoichiometric, and positional analyses of m6A at single-nucleotide resolution across the whole transcriptome level. Information on the m6A stoichiometry will provide additional layers of gene regulatory pathways mediated by m6A modification during diverse molecular, cellular, and physiological events.",

keywords = "chemical-assisted sequencing, mA modification, mA-SAC-seq, quantitative analysis, stoichiometry",

author = "Yoon, {Ki Jun} and Kim, {Yoon Ki}",

note = "Funding Information: This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIP; NRF-2015R1A3A2033665 and NRF-2018R1A5A1024261 to Y.K.K; and 2019R1C1C1006600 and 2020M3A9E4039670 to K-J.Y.). Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

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doi = "10.1016/j.tig.2022.06.009",

language = "English",

volume = "38",

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AU - Yoon, Ki Jun

AU - Kim, Yoon Ki

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N2 - A recent study by Hu et al. describes N6-methyladenosine (m6A)-selective allyl chemical labeling and sequencing (m6A-SAC-seq), which allows for quantitative, stoichiometric, and positional analyses of m6A at single-nucleotide resolution across the whole transcriptome level. Information on the m6A stoichiometry will provide additional layers of gene regulatory pathways mediated by m6A modification during diverse molecular, cellular, and physiological events.

AB - A recent study by Hu et al. describes N6-methyladenosine (m6A)-selective allyl chemical labeling and sequencing (m6A-SAC-seq), which allows for quantitative, stoichiometric, and positional analyses of m6A at single-nucleotide resolution across the whole transcriptome level. Information on the m6A stoichiometry will provide additional layers of gene regulatory pathways mediated by m6A modification during diverse molecular, cellular, and physiological events.

KW - chemical-assisted sequencing

KW - mA modification

KW - mA-SAC-seq

KW - quantitative analysis

KW - stoichiometry

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DO - 10.1016/j.tig.2022.06.009

M3 - Short survey

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AN - SCOPUS:85133680734

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