Resveratrol Oligomers, Plant-Produced Natural Products With Anti-virulence and Plant Immune-Priming Roles

Ji Eun Kang, Nayeon Yoo, Byeong Jun Jeon, Beom Seok Kim, Eui Hwan Chung

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Antibiotic resistance has become increasingly prevalent in the environment. Many alternative strategies have been proposed for the treatment and prevention of diverse diseases in agriculture. Among them, the modulation of bacterial virulence to bypass antibiotic resistance or boost plant innate immunity can be considered a promising drug target. Plant-produced natural products offer a broad spectrum of stereochemistry and a wide range of pharmacophores, providing a great diversity of biological activities. Here, we present a perspective on the putative role of plant-produced resveratrol oligomers as anti-virulence and plant-immune priming agents for efficient disease management. Resveratrol oligomers can decrease (1) bacterial motility directly and (2) indirectly by attenuating the bacterial type III secretion system (TT3S). They induce enhanced local immune responses mediated by two-layered plant innate immunity, demonstrating (3) a putative plant immune priming role.

Original languageEnglish
Article number885625
JournalFrontiers in Plant Science
Publication statusPublished - 2022 May 27

Bibliographical note

Publisher Copyright:
Copyright © 2022 Kang, Yoo, Jeon, Kim and Chung.


  • anti-virulence
  • immune-priming
  • resveratrol oligomers
  • stilbene
  • type III secretion system (TT3S)

ASJC Scopus subject areas

  • Plant Science


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