Abstract
Retinoic acid (RA) inhibited proliferation of cultured human keratinocytes. Southern blot analysis at 24 h showed that RA inhibited nerve growth factor (NGF) mRNA synthesis in a dose-dependent manner. However, RA stimulated the production of NGF protein up to 187% of control after 96 h and the treatment of cells with RA did not enhance apoptosis, either in the presence of low or high concentration of Ca2+, when compared to the control with DMSO.
Original language | English |
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Pages (from-to) | 2035-2040 |
Number of pages | 6 |
Journal | Biotechnology letters |
Volume | 24 |
Issue number | 24 |
DOIs | |
Publication status | Published - 2002 Dec |
Keywords
- Apoptosis
- Keratinocyte
- Nerve growth factor
- Proliferation
- Retinoic acid
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Applied Microbiology and Biotechnology