Abstract
Transcriptional coactivators SRC-1 and p300 specifically interact with liganded-nuclear receptors and also modulate other transcription factors, including serum response factor (SRF). Here, we report that retinoids repress transactivation by SRF and specific interactions exist between the DNA binding domains of SRF and retinoic acid and retinoid X receptors. We further demonstrate that the repression may involve retinoid-dependent competition for a limiting amount of SRC-1 and p300 between SRF and retinoid receptors. We propose that the well-defined anti-proliferative action of retinoids could, at least in part, result from this novel transrepressive action on the mitogenic transcription factor SRF.
| Original language | English |
|---|---|
| Pages (from-to) | 6638-6642 |
| Number of pages | 5 |
| Journal | Oncogene |
| Volume | 20 |
| Issue number | 45 |
| DOIs | |
| Publication status | Published - 2001 Oct 4 |
| Externally published | Yes |
Bibliographical note
Funding Information:We thank Drs Larry Jameson and Richard Treisman for plasmids. This research was exclusively supported by a grant from the National Creative Research Initiatives Program of the Korean Ministry of Science and Technology.
Keywords
- Coactivator
- Nuclear receptors
- Retinoids
- SRF
- Transcription
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cancer Research
