Reverse freeze casting: A new method for fabricating highly porous titanium scaffolds with aligned large pores

Se Won Yook; Hyun Do Jung; Chang Hoon Park; Kwan Ha Shin; Young Hag Koh; Yuri Estrin; Hyoun Ee Kim

doi:10.1016/j.actbio.2012.03.020

Reverse freeze casting: A new method for fabricating highly porous titanium scaffolds with aligned large pores

Se Won Yook, Hyun Do Jung, Chang Hoon Park, Kwan Ha Shin, Young Hag Koh, Yuri Estrin, Hyoun Ee Kim

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Abstract

Highly porous titanium with aligned large pores up to 500 μm in size, which is suitable for scaffold applications, was successfully fabricated using the reverse freeze casting method. In this process we have newly developed, the Ti powders migrated spontaneously along the pre-aligned camphene boundaries at a temperature of 45.5 °C and formed a titanium-camphene mixture with an aligned structure; this was followed by freeze drying and sintering. As the casting time increased from 24 to 48 h, the initial columnar structures turned into lamellar structures, with the porosity decreasing from 69 to 51%. This reduction in porosity caused the compressive yield strength to increase from 121 to 302 MPa, with an elastic modulus of the samples being in the range of 2-5 GPa. In addition, it was demonstrated that reverse freeze casting can also be successfully applied to various other raw powders, suggesting that the method developed in this work opens up new avenues for the production of a range of porous metallic and ceramic scaffolds with highly aligned pores.

Original language	English
Pages (from-to)	2401-2410
Number of pages	10
Journal	Acta Biomaterialia
Volume	8
Issue number	6
DOIs	https://doi.org/10.1016/j.actbio.2012.03.020
Publication status	Published - 2012 Jul

Bibliographical note

Funding Information:
This research was supported by WCU (World Class University) project through National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (R31-2008-000-10075-0) and by the International Collaborative R&D Program (No. 2010-BS-101007-001) program funded by the Ministry of Knowledge & Economy, Republic of Korea.

Keywords

Aligned pores
Freeze casting
Mechanical properties
Scaffold
Titanium (Ti)

ASJC Scopus subject areas

Biotechnology
Biomaterials
Biochemistry
Biomedical Engineering
Molecular Biology

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10.1016/j.actbio.2012.03.020

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abstract = "Highly porous titanium with aligned large pores up to 500 μm in size, which is suitable for scaffold applications, was successfully fabricated using the reverse freeze casting method. In this process we have newly developed, the Ti powders migrated spontaneously along the pre-aligned camphene boundaries at a temperature of 45.5 °C and formed a titanium-camphene mixture with an aligned structure; this was followed by freeze drying and sintering. As the casting time increased from 24 to 48 h, the initial columnar structures turned into lamellar structures, with the porosity decreasing from 69 to 51%. This reduction in porosity caused the compressive yield strength to increase from 121 to 302 MPa, with an elastic modulus of the samples being in the range of 2-5 GPa. In addition, it was demonstrated that reverse freeze casting can also be successfully applied to various other raw powders, suggesting that the method developed in this work opens up new avenues for the production of a range of porous metallic and ceramic scaffolds with highly aligned pores.",

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note = "Funding Information: This research was supported by WCU (World Class University) project through National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (R31-2008-000-10075-0) and by the International Collaborative R&D Program (No. 2010-BS-101007-001) program funded by the Ministry of Knowledge & Economy, Republic of Korea. ",

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AU - Koh, Young Hag

AU - Estrin, Yuri

AU - Kim, Hyoun Ee

N1 - Funding Information: This research was supported by WCU (World Class University) project through National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (R31-2008-000-10075-0) and by the International Collaborative R&D Program (No. 2010-BS-101007-001) program funded by the Ministry of Knowledge & Economy, Republic of Korea.

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N2 - Highly porous titanium with aligned large pores up to 500 μm in size, which is suitable for scaffold applications, was successfully fabricated using the reverse freeze casting method. In this process we have newly developed, the Ti powders migrated spontaneously along the pre-aligned camphene boundaries at a temperature of 45.5 °C and formed a titanium-camphene mixture with an aligned structure; this was followed by freeze drying and sintering. As the casting time increased from 24 to 48 h, the initial columnar structures turned into lamellar structures, with the porosity decreasing from 69 to 51%. This reduction in porosity caused the compressive yield strength to increase from 121 to 302 MPa, with an elastic modulus of the samples being in the range of 2-5 GPa. In addition, it was demonstrated that reverse freeze casting can also be successfully applied to various other raw powders, suggesting that the method developed in this work opens up new avenues for the production of a range of porous metallic and ceramic scaffolds with highly aligned pores.

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Reverse freeze casting: A new method for fabricating highly porous titanium scaffolds with aligned large pores

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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