Review of endocrine disruptors on male and female reproductive systems

Hyekyoung Hannah You, Gwonhwa Song

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)


Endocrine disruptors (EDs) interfere with different hormonal and metabolic processes and disrupt the development of organs and tissues, as well as the reproductive system. In toxicology research, various animal models have been utilized to compare and characterize the effects of EDs. We reviewed studies assessing the effect of ED exposure in humans, zebrafish, and mouse models and the adverse effects of EDs on male and female reproductive systems. This review outlines the distinctive morphological characteristics, as well as gene expression, factors, and mechanisms that are known to occur in response to EDs. In each animal model, disturbances in the reproductive system were associated with certain factors of apoptosis, the hypothalamic-pituitary-gonadal axis, estrogen receptor pathway-induced meiotic disruption, and steroidogenesis. The effects of bisphenol A, phthalate, and 17α-ethinylestradiol have been investigated in animal models, each providing supporting outcomes and elaborating the key regulators of male and female reproductive systems.

Original languageEnglish
Article number109002
JournalComparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology
Publication statusPublished - 2021 Jun

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc.


  • Endocrine disruptors
  • Human
  • Reproductive system
  • Rodent model
  • Zebrafish model

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Aquatic Science
  • Animal Science and Zoology
  • Toxicology
  • Cell Biology
  • Health, Toxicology and Mutagenesis


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