Rhapontigenin converted from rhapontin purified from rheum undulatum enhances the inhibition of melanin synthesis

Hyun Sun Lee; Jeong Keun Kim; Keun Tae Park; Young Hee Lim

doi:10.1271/bbb.120229

Rhapontigenin converted from rhapontin purified from rheum undulatum enhances the inhibition of melanin synthesis

Hyun Sun Lee, Jeong Keun Kim, Keun Tae Park, Young Hee Lim

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Rhapontigenin was produced from rhapontin isolated from a methanol extract of Rheum undulatum roots by enzymatic transformation. Rhapontin and rhapontigenin exhibited dose-dependent inhibition of tyrosinase activity and melanin synthesis in B16F10 melanoma cells, but the inhibitory activity of rhapontigenin was greater than that of rhapontin. Thus the bioconversion of rhapontin enhanced its ability to inhibit cellular tyrosinase activity and melanin synthesis.

Original language	English
Pages (from-to)	2307-2309
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	76
Issue number	12
DOIs	https://doi.org/10.1271/bbb.120229
Publication status	Published - 2012

Bibliographical note

Funding Information:
This study was supported by the Technology Development Program for Agricultural and Forestry of the Ministry for Food, Agriculture, Forestry, and Fisheries of the Republic of Korea (20080563).

Keywords

Aglycone
Bioconversion
Melanin synthesis inhibition
Rhapontigenin
Tyrosinase

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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10.1271/bbb.120229

Cite this

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title = "Rhapontigenin converted from rhapontin purified from rheum undulatum enhances the inhibition of melanin synthesis",

abstract = "Rhapontigenin was produced from rhapontin isolated from a methanol extract of Rheum undulatum roots by enzymatic transformation. Rhapontin and rhapontigenin exhibited dose-dependent inhibition of tyrosinase activity and melanin synthesis in B16F10 melanoma cells, but the inhibitory activity of rhapontigenin was greater than that of rhapontin. Thus the bioconversion of rhapontin enhanced its ability to inhibit cellular tyrosinase activity and melanin synthesis.",

keywords = "Aglycone, Bioconversion, Melanin synthesis inhibition, Rhapontigenin, Tyrosinase",

author = "Lee, {Hyun Sun} and Kim, {Jeong Keun} and Park, {Keun Tae} and Lim, {Young Hee}",

note = "Funding Information: This study was supported by the Technology Development Program for Agricultural and Forestry of the Ministry for Food, Agriculture, Forestry, and Fisheries of the Republic of Korea (20080563).",

year = "2012",

doi = "10.1271/bbb.120229",

language = "English",

volume = "76",

pages = "2307--2309",

journal = "Bioscience, Biotechnology and Biochemistry",

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publisher = "Oxford University Press",

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T1 - Rhapontigenin converted from rhapontin purified from rheum undulatum enhances the inhibition of melanin synthesis

AU - Lee, Hyun Sun

AU - Kim, Jeong Keun

AU - Park, Keun Tae

AU - Lim, Young Hee

N1 - Funding Information: This study was supported by the Technology Development Program for Agricultural and Forestry of the Ministry for Food, Agriculture, Forestry, and Fisheries of the Republic of Korea (20080563).

PY - 2012

Y1 - 2012

N2 - Rhapontigenin was produced from rhapontin isolated from a methanol extract of Rheum undulatum roots by enzymatic transformation. Rhapontin and rhapontigenin exhibited dose-dependent inhibition of tyrosinase activity and melanin synthesis in B16F10 melanoma cells, but the inhibitory activity of rhapontigenin was greater than that of rhapontin. Thus the bioconversion of rhapontin enhanced its ability to inhibit cellular tyrosinase activity and melanin synthesis.

AB - Rhapontigenin was produced from rhapontin isolated from a methanol extract of Rheum undulatum roots by enzymatic transformation. Rhapontin and rhapontigenin exhibited dose-dependent inhibition of tyrosinase activity and melanin synthesis in B16F10 melanoma cells, but the inhibitory activity of rhapontigenin was greater than that of rhapontin. Thus the bioconversion of rhapontin enhanced its ability to inhibit cellular tyrosinase activity and melanin synthesis.

KW - Aglycone

KW - Bioconversion

KW - Melanin synthesis inhibition

KW - Rhapontigenin

KW - Tyrosinase

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DO - 10.1271/bbb.120229

M3 - Article

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AN - SCOPUS:84871628625

SN - 0916-8451

VL - 76

SP - 2307

EP - 2309

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 12

ER -

Rhapontigenin converted from rhapontin purified from rheum undulatum enhances the inhibition of melanin synthesis

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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