Rho-kinase as a target for cancer therapy and its immunotherapeutic potential

Seohyun Kim; Seong A. Kim; Jihoon Han; In San Kim

doi:10.3390/ijms222312916

Rho-kinase as a target for cancer therapy and its immunotherapeutic potential

Seohyun Kim, Seong A. Kim, Jihoon Han, In San Kim

Research output: Contribution to journal › Review article › peer-review

42 Citations (Scopus)

Abstract

Cancer immunotherapy is fast rising as a prominent new pillar of cancer treatment, harnessing the immune system to fight against numerous types of cancer. Rho-kinase (ROCK) pathway is involved in diverse cellular activities, and is therefore the target of interest in various diseases at the cellular level including cancer. Indeed, ROCK is well-known for its involvement in the tumor cell and tumor microenvironment, especially in its ability to enhance tumor cell progression, migration, metastasis, and extracellular matrix remodeling. Importantly, ROCK is also considered to be a novel and effective modulator of immune cells, although further studies are needed. In this review article, we describe the various activities of ROCK and its potential to be utilized in cancer treatment, particularly in cancer immunotherapy, by shining a light on its activities in the immune system.

Original language	English
Article number	12916
Journal	International journal of molecular sciences
Volume	22
Issue number	23
DOIs	https://doi.org/10.3390/ijms222312916
Publication status	Published - 2021 Dec 1

Bibliographical note

Funding Information:
Funding: This research was funded by grants from the National Research Foundation of Korea (NRF) funded by the Korean government (2017R1A3B1023418), KU-KIST Graduate School of Converging Science and Technology Program, National Cancer Center of Korea, and KIST Institutional Programs.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Cancer immunotherapy
ROCK inhibitors
Rho-kinase (ROCK)
Tumor microenvironment (TME)

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms222312916

Cite this

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title = "Rho-kinase as a target for cancer therapy and its immunotherapeutic potential",

abstract = "Cancer immunotherapy is fast rising as a prominent new pillar of cancer treatment, harnessing the immune system to fight against numerous types of cancer. Rho-kinase (ROCK) pathway is involved in diverse cellular activities, and is therefore the target of interest in various diseases at the cellular level including cancer. Indeed, ROCK is well-known for its involvement in the tumor cell and tumor microenvironment, especially in its ability to enhance tumor cell progression, migration, metastasis, and extracellular matrix remodeling. Importantly, ROCK is also considered to be a novel and effective modulator of immune cells, although further studies are needed. In this review article, we describe the various activities of ROCK and its potential to be utilized in cancer treatment, particularly in cancer immunotherapy, by shining a light on its activities in the immune system.",

keywords = "Cancer immunotherapy, ROCK inhibitors, Rho-kinase (ROCK), Tumor microenvironment (TME)",

author = "Seohyun Kim and Kim, {Seong A.} and Jihoon Han and Kim, {In San}",

note = "Funding Information: Funding: This research was funded by grants from the National Research Foundation of Korea (NRF) funded by the Korean government (2017R1A3B1023418), KU-KIST Graduate School of Converging Science and Technology Program, National Cancer Center of Korea, and KIST Institutional Programs. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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AU - Kim, Seohyun

AU - Kim, Seong A.

AU - Han, Jihoon

AU - Kim, In San

N1 - Funding Information: Funding: This research was funded by grants from the National Research Foundation of Korea (NRF) funded by the Korean government (2017R1A3B1023418), KU-KIST Graduate School of Converging Science and Technology Program, National Cancer Center of Korea, and KIST Institutional Programs. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/12/1

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N2 - Cancer immunotherapy is fast rising as a prominent new pillar of cancer treatment, harnessing the immune system to fight against numerous types of cancer. Rho-kinase (ROCK) pathway is involved in diverse cellular activities, and is therefore the target of interest in various diseases at the cellular level including cancer. Indeed, ROCK is well-known for its involvement in the tumor cell and tumor microenvironment, especially in its ability to enhance tumor cell progression, migration, metastasis, and extracellular matrix remodeling. Importantly, ROCK is also considered to be a novel and effective modulator of immune cells, although further studies are needed. In this review article, we describe the various activities of ROCK and its potential to be utilized in cancer treatment, particularly in cancer immunotherapy, by shining a light on its activities in the immune system.

AB - Cancer immunotherapy is fast rising as a prominent new pillar of cancer treatment, harnessing the immune system to fight against numerous types of cancer. Rho-kinase (ROCK) pathway is involved in diverse cellular activities, and is therefore the target of interest in various diseases at the cellular level including cancer. Indeed, ROCK is well-known for its involvement in the tumor cell and tumor microenvironment, especially in its ability to enhance tumor cell progression, migration, metastasis, and extracellular matrix remodeling. Importantly, ROCK is also considered to be a novel and effective modulator of immune cells, although further studies are needed. In this review article, we describe the various activities of ROCK and its potential to be utilized in cancer treatment, particularly in cancer immunotherapy, by shining a light on its activities in the immune system.

KW - Cancer immunotherapy

KW - ROCK inhibitors

KW - Rho-kinase (ROCK)

KW - Tumor microenvironment (TME)

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U2 - 10.3390/ijms222312916

DO - 10.3390/ijms222312916

M3 - Review article

C2 - 34884721

AN - SCOPUS:85120052989

SN - 1661-6596

VL - 22

JO - International journal of molecular sciences

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IS - 23

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ER -

Rho-kinase as a target for cancer therapy and its immunotherapeutic potential

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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