Ribosomal protein S3-derived repair domain peptides regulate UV-induced matrix metalloproteinase-1

Hee Woong Yang, Youjin Jung, Hag Dong Kim, Joon Kim

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Ultraviolet (UV) radiation is a major factor that causes wrinkle formation by affecting the collagen level in the skin. Here, we show that a short peptide (A8) derived from the repair domain of the ribosomal protein S3 (rpS3) reduces UV irradiation-induced increase in matrix metalloproteinase-1 (MMP-1) and prevents collagen degradation by reducing the activation of the mitogen-activated protein kinase (MAPK) signaling proteins (extracellular signal-regulated kinase [ERK], p38, and c-Jun N-terminal kinases [JNK]) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) in cells. Furthermore, A8 also prevents the increase in the levels of inflammatory modulators such as tumor necrosis factor-alpha (TNF-α) or interleukin-6 (IL-6) in UV-irradiated cells. Collectively, our study suggests that the A8 peptide, derived from yeast or human, has anti-photoaging potential as it prevents UV-induced wrinkle formation.

Original languageEnglish
Pages (from-to)149-154
Number of pages6
JournalBiochemical and biophysical research communications
Issue number1
Publication statusPublished - 2020 Sept 10

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea [ 2019S1A5A2A03050121 ].

Publisher Copyright:
© 2020 Elsevier Inc.


  • Collagen
  • MAPK/NF-κB pathway
  • MMP-1
  • Photoaging
  • rpS3

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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