Ribosomal protein S3 is secreted as a homodimer in cancer cells

Yong Joong Kim, Hag Dong Kim, Bu Hyun Youn, Yun Gyu Park, Joon Kim

    Research output: Contribution to journalArticlepeer-review

    19 Citations (Scopus)

    Abstract

    Protein secretion is a general phenomenon by which cells communicate with the extracellular environment. Secretory proteins, including hormones, enzymes, toxins, and antimicrobial peptides have various functions in extracellular environments. Here, we determined that ribosomal protein S3 (rpS3) is homodimerized and secreted in several cancer cell lines such as HT1080 (human fibrosarcoma) and MPC11 (mouse plasmacytoma). Moreover, we found that the secreted rpS3 protein increased in doxorubicin-resistant MPC11 cells compared to that in MPC11 cells. In addition, we also detected that the level of secreted rpS3 increased in more malignant cells, which were established with continuous exposure of cigarette smoke condensate. These findings suggest that the secreted rpS3 protein is an indicator of malignant tumors.

    Original languageEnglish
    Pages (from-to)805-808
    Number of pages4
    JournalBiochemical and biophysical research communications
    Volume441
    Issue number4
    DOIs
    Publication statusPublished - 2013 Nov 29

    Bibliographical note

    Funding Information:
    This work was supported in part by NRF-2013R1A1A2012052 and Korea University grants and Kim HD was supported by 2012R1A2A1A01009027 and Korea University Fellowship.

    Keywords

    • Dimerization
    • Ribosomal protein S3
    • Ribosome
    • Secretion

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Molecular Biology
    • Cell Biology

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