Ribosomal protein S3 is secreted as a homodimer in cancer cells

Yong Joong Kim; Hag Dong Kim; Bu Hyun Youn; Yun Gyu Park; Joon Kim

doi:10.1016/j.bbrc.2013.10.132

Ribosomal protein S3 is secreted as a homodimer in cancer cells

Yong Joong Kim
, Hag Dong Kim
, Bu Hyun Youn
, Yun Gyu Park
, Joon Kim^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Protein secretion is a general phenomenon by which cells communicate with the extracellular environment. Secretory proteins, including hormones, enzymes, toxins, and antimicrobial peptides have various functions in extracellular environments. Here, we determined that ribosomal protein S3 (rpS3) is homodimerized and secreted in several cancer cell lines such as HT1080 (human fibrosarcoma) and MPC11 (mouse plasmacytoma). Moreover, we found that the secreted rpS3 protein increased in doxorubicin-resistant MPC11 cells compared to that in MPC11 cells. In addition, we also detected that the level of secreted rpS3 increased in more malignant cells, which were established with continuous exposure of cigarette smoke condensate. These findings suggest that the secreted rpS3 protein is an indicator of malignant tumors.

Original language	English
Pages (from-to)	805-808
Number of pages	4
Journal	Biochemical and biophysical research communications
Volume	441
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2013.10.132
Publication status	Published - 2013 Nov 29

Bibliographical note

Funding Information:
This work was supported in part by NRF-2013R1A1A2012052 and Korea University grants and Kim HD was supported by 2012R1A2A1A01009027 and Korea University Fellowship.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Dimerization
Ribosomal protein S3
Ribosome
Secretion

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2013.10.132

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title = "Ribosomal protein S3 is secreted as a homodimer in cancer cells",

abstract = "Protein secretion is a general phenomenon by which cells communicate with the extracellular environment. Secretory proteins, including hormones, enzymes, toxins, and antimicrobial peptides have various functions in extracellular environments. Here, we determined that ribosomal protein S3 (rpS3) is homodimerized and secreted in several cancer cell lines such as HT1080 (human fibrosarcoma) and MPC11 (mouse plasmacytoma). Moreover, we found that the secreted rpS3 protein increased in doxorubicin-resistant MPC11 cells compared to that in MPC11 cells. In addition, we also detected that the level of secreted rpS3 increased in more malignant cells, which were established with continuous exposure of cigarette smoke condensate. These findings suggest that the secreted rpS3 protein is an indicator of malignant tumors.",

keywords = "Dimerization, Ribosomal protein S3, Ribosome, Secretion",

author = "Kim, \{Yong Joong\} and Kim, \{Hag Dong\} and Youn, \{Bu Hyun\} and Park, \{Yun Gyu\} and Joon Kim",

note = "Funding Information: This work was supported in part by NRF-2013R1A1A2012052 and Korea University grants and Kim HD was supported by 2012R1A2A1A01009027 and Korea University Fellowship.",

year = "2013",

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doi = "10.1016/j.bbrc.2013.10.132",

language = "English",

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journal = "Biochemical and biophysical research communications",

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AU - Kim, Yong Joong

AU - Kim, Hag Dong

AU - Youn, Bu Hyun

AU - Park, Yun Gyu

AU - Kim, Joon

N1 - Funding Information: This work was supported in part by NRF-2013R1A1A2012052 and Korea University grants and Kim HD was supported by 2012R1A2A1A01009027 and Korea University Fellowship.

PY - 2013/11/29

Y1 - 2013/11/29

N2 - Protein secretion is a general phenomenon by which cells communicate with the extracellular environment. Secretory proteins, including hormones, enzymes, toxins, and antimicrobial peptides have various functions in extracellular environments. Here, we determined that ribosomal protein S3 (rpS3) is homodimerized and secreted in several cancer cell lines such as HT1080 (human fibrosarcoma) and MPC11 (mouse plasmacytoma). Moreover, we found that the secreted rpS3 protein increased in doxorubicin-resistant MPC11 cells compared to that in MPC11 cells. In addition, we also detected that the level of secreted rpS3 increased in more malignant cells, which were established with continuous exposure of cigarette smoke condensate. These findings suggest that the secreted rpS3 protein is an indicator of malignant tumors.

AB - Protein secretion is a general phenomenon by which cells communicate with the extracellular environment. Secretory proteins, including hormones, enzymes, toxins, and antimicrobial peptides have various functions in extracellular environments. Here, we determined that ribosomal protein S3 (rpS3) is homodimerized and secreted in several cancer cell lines such as HT1080 (human fibrosarcoma) and MPC11 (mouse plasmacytoma). Moreover, we found that the secreted rpS3 protein increased in doxorubicin-resistant MPC11 cells compared to that in MPC11 cells. In addition, we also detected that the level of secreted rpS3 increased in more malignant cells, which were established with continuous exposure of cigarette smoke condensate. These findings suggest that the secreted rpS3 protein is an indicator of malignant tumors.

KW - Dimerization

KW - Ribosomal protein S3

KW - Ribosome

KW - Secretion

UR - https://www.scopus.com/pages/publications/84888836601

U2 - 10.1016/j.bbrc.2013.10.132

DO - 10.1016/j.bbrc.2013.10.132

M3 - Article

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AN - SCOPUS:84888836601

SN - 0006-291X

VL - 441

SP - 805

EP - 808

JO - Biochemical and biophysical research communications

JF - Biochemical and biophysical research communications

IS - 4

ER -

Ribosomal protein S3 is secreted as a homodimer in cancer cells

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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