Risk factors for neurologic complications of hand, foot and mouth disease in the Republic of Korea, 2009

Seong Joon Kim; Jong Hyun Kim; Jin Han Kang; Dong Soo Kim; Ki Hwan Kim; Kyung Hyo Kim; Young Hoon Kim; Ju Young Chung; Joong Hyun Bin; Da Eun Jung; Ji Hong Kim; Hwang Min Kim; Doo Sung Cheon; Byung Hak Kang; Soon Young Seo; Byung Min Choi; Eun Hwa Choi; Jae Yoon Kim; Jung Yeun Hong; Sung Hee Oh; Sung Ho Cha; Yae Jean Kim

doi:10.3346/jkms.2013.28.1.120

Risk factors for neurologic complications of hand, foot and mouth disease in the Republic of Korea, 2009

Seong Joon Kim, Jong Hyun Kim, Jin Han Kang, Dong Soo Kim, Ki Hwan Kim, Kyung Hyo Kim, Young Hoon Kim, Ju Young Chung, Joong Hyun Bin, Da Eun Jung, Ji Hong Kim, Hwang Min Kim, Doo Sung Cheon, Byung Hak Kang, Soon Young Seo, Byung Min Choi, Eun Hwa Choi, Jae Yoon Kim, Jung Yeun Hong, Sung Hee OhSung Ho Cha, Yae Jean Kim

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

In 2009, the first outbreak of hand, foot and mouth disease (HFMD) or herpangina (HP) caused by enterovirus 71 occurred in the Republic of Korea. This study inquired into risk factors associated with complications of HFMD or HP. A retrospective medical records review was conducted on HFMD or HP patients for whom etiologic viruses had been verified in 2009. One hundred sixty-eight patients were examined for this investigation. Eighty patients were without complications while 88 were accompanied by complications, and 2 had expired. Enterovirus 71 subgenotype C4a was the most prevalent in number with 67 cases (54.9%). In the univariate analysis, the disease patterns of HFMD rather than HP, fever longer than 4 days, peak body temperature over 39°C, vomiting, headache, neurologic signs, serum glucose over 100 mg/dL, and having an enterovirus 71 as a causative virus were significant risk factors of the complications. After multiple logistic analysis, headache (Odds ratio [OR], 10.75; P < 0.001) and neurologic signs (OR, 42.76; P < 0.001) were found to be the most significant factors. Early detection and proper management of patients with aforementioned risk factors would be necessary in order to attain a better clinical outcome.

Original language	English
Pages (from-to)	120-127
Number of pages	8
Journal	Journal of Korean medical science
Volume	28
Issue number	1
DOIs	https://doi.org/10.3346/jkms.2013.28.1.120
Publication status	Published - 2013
Externally published	Yes

Keywords

Coxsackievirus
Enterovirus A, human
Hand, foot and mouth disease
Herpangina
Risk factors

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3346/jkms.2013.28.1.120

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Kim, S. J., Kim, J. H., Kang, J. H., Kim, D. S., Kim, K. H., Kim, K. H., Kim, Y. H., Chung, J. Y., Bin, J. H., Jung, D. E., Kim, J. H., Kim, H. M., Cheon, D. S., Kang, B. H., Seo, S. Y., Choi, B. M., Choi, E. H., Kim, J. Y., Hong, J. Y., ... Kim, Y. J. (2013). Risk factors for neurologic complications of hand, foot and mouth disease in the Republic of Korea, 2009. Journal of Korean medical science, 28(1), 120-127. https://doi.org/10.3346/jkms.2013.28.1.120

Kim, SJ, Kim, JH, Kang, JH, Kim, DS, Kim, KH, Kim, KH, Kim, YH, Chung, JY, Bin, JH, Jung, DE, Kim, JH, Kim, HM, Cheon, DS, Kang, BH, Seo, SY, Choi, BM, Choi, EH, Kim, JY, Hong, JY, Oh, SH, Cha, SH & Kim, YJ 2013, 'Risk factors for neurologic complications of hand, foot and mouth disease in the Republic of Korea, 2009', Journal of Korean medical science, vol. 28, no. 1, pp. 120-127. https://doi.org/10.3346/jkms.2013.28.1.120

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title = "Risk factors for neurologic complications of hand, foot and mouth disease in the Republic of Korea, 2009",

abstract = "In 2009, the first outbreak of hand, foot and mouth disease (HFMD) or herpangina (HP) caused by enterovirus 71 occurred in the Republic of Korea. This study inquired into risk factors associated with complications of HFMD or HP. A retrospective medical records review was conducted on HFMD or HP patients for whom etiologic viruses had been verified in 2009. One hundred sixty-eight patients were examined for this investigation. Eighty patients were without complications while 88 were accompanied by complications, and 2 had expired. Enterovirus 71 subgenotype C4a was the most prevalent in number with 67 cases (54.9%). In the univariate analysis, the disease patterns of HFMD rather than HP, fever longer than 4 days, peak body temperature over 39°C, vomiting, headache, neurologic signs, serum glucose over 100 mg/dL, and having an enterovirus 71 as a causative virus were significant risk factors of the complications. After multiple logistic analysis, headache (Odds ratio [OR], 10.75; P < 0.001) and neurologic signs (OR, 42.76; P < 0.001) were found to be the most significant factors. Early detection and proper management of patients with aforementioned risk factors would be necessary in order to attain a better clinical outcome.",

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AU - Kim, Seong Joon

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AU - Kang, Jin Han

AU - Kim, Dong Soo

AU - Kim, Ki Hwan

AU - Kim, Kyung Hyo

AU - Kim, Young Hoon

AU - Chung, Ju Young

AU - Bin, Joong Hyun

AU - Jung, Da Eun

AU - Kim, Ji Hong

AU - Kim, Hwang Min

AU - Cheon, Doo Sung

AU - Kang, Byung Hak

AU - Seo, Soon Young

AU - Choi, Byung Min

AU - Choi, Eun Hwa

AU - Kim, Jae Yoon

AU - Hong, Jung Yeun

AU - Oh, Sung Hee

AU - Cha, Sung Ho

AU - Kim, Yae Jean

PY - 2013

Y1 - 2013

N2 - In 2009, the first outbreak of hand, foot and mouth disease (HFMD) or herpangina (HP) caused by enterovirus 71 occurred in the Republic of Korea. This study inquired into risk factors associated with complications of HFMD or HP. A retrospective medical records review was conducted on HFMD or HP patients for whom etiologic viruses had been verified in 2009. One hundred sixty-eight patients were examined for this investigation. Eighty patients were without complications while 88 were accompanied by complications, and 2 had expired. Enterovirus 71 subgenotype C4a was the most prevalent in number with 67 cases (54.9%). In the univariate analysis, the disease patterns of HFMD rather than HP, fever longer than 4 days, peak body temperature over 39°C, vomiting, headache, neurologic signs, serum glucose over 100 mg/dL, and having an enterovirus 71 as a causative virus were significant risk factors of the complications. After multiple logistic analysis, headache (Odds ratio [OR], 10.75; P < 0.001) and neurologic signs (OR, 42.76; P < 0.001) were found to be the most significant factors. Early detection and proper management of patients with aforementioned risk factors would be necessary in order to attain a better clinical outcome.

AB - In 2009, the first outbreak of hand, foot and mouth disease (HFMD) or herpangina (HP) caused by enterovirus 71 occurred in the Republic of Korea. This study inquired into risk factors associated with complications of HFMD or HP. A retrospective medical records review was conducted on HFMD or HP patients for whom etiologic viruses had been verified in 2009. One hundred sixty-eight patients were examined for this investigation. Eighty patients were without complications while 88 were accompanied by complications, and 2 had expired. Enterovirus 71 subgenotype C4a was the most prevalent in number with 67 cases (54.9%). In the univariate analysis, the disease patterns of HFMD rather than HP, fever longer than 4 days, peak body temperature over 39°C, vomiting, headache, neurologic signs, serum glucose over 100 mg/dL, and having an enterovirus 71 as a causative virus were significant risk factors of the complications. After multiple logistic analysis, headache (Odds ratio [OR], 10.75; P < 0.001) and neurologic signs (OR, 42.76; P < 0.001) were found to be the most significant factors. Early detection and proper management of patients with aforementioned risk factors would be necessary in order to attain a better clinical outcome.

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ER -

Risk factors for neurologic complications of hand, foot and mouth disease in the Republic of Korea, 2009

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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