Conjugation of antibiotic vancomycin (VAN) on nanoparticles (NPs) has recently initiated novel works in the nanobiotechnology field. In this study, a bioelectronic structure using VAN conjugated zinc oxide (ZnO) NPs as charge storing elements on metal-pentacene-insulator-silicon (MPIS) device is demonstrated. Highly specific molecular recognition between the VAN and membrane protein unit mimicked from VAN-resistant bacteria is employed as the formation mechanism of self-assembly monolayers (SAMs) of ZnO NPs. The insulator surface is modified with the VAN cognate peptide of l-Ala-d-Glu-l-Lys-d-Ala-d-Ala by chemical activator coupling. Hysteretic behaviors in capacitance versus voltage (C-V) curves are obtained for the charged ZnO NPs exhibiting flatband voltage shifts, which demonstrate the charge storage on the VAN conjugated ZnO NPs. The potential perspective of this study will be a tangible progress of biomolecular electronics implemented by the interface between biomolecules and electronics.
Bibliographical noteFunding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2010-0024548 ). This research was also supported by Nano-Material Technology Development Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (No. 2011-0030228 ).
- Memory device
- Self-assembly monolayer
- ZnO nanoparticles
ASJC Scopus subject areas
- Biomedical Engineering