TY - JOUR
T1 - Rogue cell-like chromosomal aberrations in peripheral blood lymphocytes of interventional radiologists
T2 - A case study
AU - Jang, Seongjae
AU - Lee, Younghyun
AU - Songwon, Seo
AU - Jin, Young Woo
AU - Lee, Won Jin
N1 - Funding Information:
This research was supported by the grants of the Korea Institute of Radiological and Medical Sciences, funded by Ministry of Science and ICT (No. 50445-2020), the Nuclear Safety and Security Commission (No. 1803014) and the Korea Ministry of Health and Welfare and Center for Disease Control and Prevention (No. 2017E3600600), Republic of Korea.
Funding Information:
This research was supported by the grants of the Korea Institute of Radiological and Medical Sciences , funded by Ministry of Science and ICT (No. 50445-2020 ), the Nuclear Safety and Security Commission (No. 1803014 ) and the Korea Ministry of Health and Welfare and Center for Disease Control and Prevention (No. 2017E3600600 ), Republic of Korea .
Publisher Copyright:
© 2020 The Authors
PY - 2020/8/1
Y1 - 2020/8/1
N2 - We report two cases of interventional radiologists who had been exposed to radiation while performing fluoroscopically-guided interventional procedures (FGIPs), mainly transcatheter arterial chemoembolization, percutaneous catheter drainage, and percutaneous transhepatic biliary drainage procedures, for over 10 years. They had a unique multi-aberrant cell type with not only high numbers of dicentrics and/or centric rings but also excess acentric double minutes, similar to a rogue cell. As revealed in a self-administered questionnaire, they wore personal dosimeters and protective equipment at all times and used shielding devices during interventional fluoroscopy procedures. However, the exposed dose levels derived from cytogenetic dosimetry were much higher than the doses recorded on their personal dosimeters. A large number of unstable and stable chromosomal aberrations that were found in the peripheral blood lymphocytes of these interventional radiologists might be due to repeated and long-term exposure to ionizing radiation while performing FGIPs. Further investigations of chromosomal aberrations in interventional radiologists may improve the understanding of the long-term effects of radiation exposure on medical personnel.
AB - We report two cases of interventional radiologists who had been exposed to radiation while performing fluoroscopically-guided interventional procedures (FGIPs), mainly transcatheter arterial chemoembolization, percutaneous catheter drainage, and percutaneous transhepatic biliary drainage procedures, for over 10 years. They had a unique multi-aberrant cell type with not only high numbers of dicentrics and/or centric rings but also excess acentric double minutes, similar to a rogue cell. As revealed in a self-administered questionnaire, they wore personal dosimeters and protective equipment at all times and used shielding devices during interventional fluoroscopy procedures. However, the exposed dose levels derived from cytogenetic dosimetry were much higher than the doses recorded on their personal dosimeters. A large number of unstable and stable chromosomal aberrations that were found in the peripheral blood lymphocytes of these interventional radiologists might be due to repeated and long-term exposure to ionizing radiation while performing FGIPs. Further investigations of chromosomal aberrations in interventional radiologists may improve the understanding of the long-term effects of radiation exposure on medical personnel.
KW - Dicentrics
KW - Dose monitoring
KW - Fluoroscopy procedures
KW - Occupational exposure
KW - Radiation protection
UR - http://www.scopus.com/inward/record.url?scp=85088642609&partnerID=8YFLogxK
U2 - 10.1016/j.mrgentox.2020.503234
DO - 10.1016/j.mrgentox.2020.503234
M3 - Article
C2 - 32928374
AN - SCOPUS:85088642609
SN - 1383-5718
VL - 856-857
JO - Mutation Research - Genetic Toxicology and Environmental Mutagenesis
JF - Mutation Research - Genetic Toxicology and Environmental Mutagenesis
M1 - 503234
ER -