Role of benzophenone-3 additive in chronic toxicity of polyethylene microplastic fragments to Daphnia magna

Jinyoung Song, Joorim Na, Dahee An, Jinho Jung

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43 Citations (Scopus)


Plastic additives may accelerate adverse effects of microplastics (MPs). This study aimed to identify the role of benzophenone-3 (BP-3) additive (10.82 ± 1.20% w/w) in chronic toxicity of polyethylene MP fragments to Daphnia magna (D. magna). MP fragments with and without BP-3 (48.37 ± 6.26 and 44.39 ± 11.16 μm, respectively) were synthesized and 4 d-old D. magna were exposed for 17 d. Daphnids exposed to MP/BP-3 fragments (98%) showed higher survival than those exposed to MP fragments (62%), which can be explained by a significantly low (p < 0.0001) bioconcentration of MP/BP-3 fragments. BP-3 leachate induced significantly low (p < 0.05) phototactic behavior of D. magna, likely leading to the low bioconcentration of MP/BP-3 fragments. Unlike MP fragments, both MP/BP-3 fragments and BP-3 additive inhibited embryonic development and offspring growth in a similar manner. Additionally, only BP-3 additive significantly induced (p < 0.05) higher lipid peroxidation in D. magna. This study suggests the critical role of plastic additives in MPs chronic toxicity to aquatic organisms, which should be further identified for other environmentally relevant plastic additives.

Original languageEnglish
Article number149638
JournalScience of the Total Environment
Publication statusPublished - 2021 Dec 15

Bibliographical note

Funding Information:
This study was supported by a grant from the National Research Foundation of Korea (NRF), funded by the Korean government ( NRF-2019R1A2C1002890 ).

Publisher Copyright:
© 2021 Elsevier B.V.


  • Benzophenone-3
  • Chronic toxicity
  • Crustacean
  • Microplastics
  • Plastic additive

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution


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