Role of confirmatory interferon-gamma release assays in school outbreaks of tuberculosis in South Korea

H. J. Kim; G. H. Lee; S. Ryoo; S. Y. Oh; J. B. Lee; J. H. Kim; C. Shin; Seung Heon Lee

doi:10.5588/ijtld.14.0636

Role of confirmatory interferon-gamma release assays in school outbreaks of tuberculosis in South Korea

H. J. Kim, G. H. Lee, S. Ryoo, S. Y. Oh, J. B. Lee, J. H. Kim, C. Shin, Seung Heon Lee

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

OBJECTIVE: To investigate the usefulness of confirmatory QuantiFERON® (QFT) testing among tuberculin skin test (TST) positive contacts to diagnose latent tuberculous infection (LTBI) in tuberculosis (TB) outbreaks among adolescents. DESIGN: We used the Korean national claims database to identify the development of active TB disease in relation to initial TST (cut-off 10 mm induration) and subsequent QFT results. RESULTS: A total of 7475 contacts in 89 schools were divided into four groups: TST-(n = 5714), TST+/QFT+(n = 534), TST+/QFT- (n = 697) and TST+ only (n = 530). The mean duration of follow-up was 3.9 ± 0.9 years. For contacts with no LTBI treatment (n = 6868), TB incidence rates per 1000 person-years (py) and the adjusted hazard ratio (HR) compared with TST-individuals were as follows: TST+/QFT+, 66.2/1000 py (HR 35.59, 95%CI 14.03-90.31, P < 0.001); TST+ only, 10.1/1000 py (HR 5.16, 95%CI 2.91-9.17, P < 0.001); TST+/QFT-, 4.0/1000 py (HR 2.05, 95%CI 1.05-4.01, P = 0.035); and TST- 2.0/1000 py. The TB progression rate was significantly higher in TST+/QFT+ than in TST+/QFT-individuals (HR 16.82, 95 CI 5.84-48.46, P < 0.001). CONCLUSION: A confirmatory QFT for TST+contacts could reduce the number of candidates for LTBI treatment after school TB outbreaks.

Original language	English
Pages (from-to)	576-581
Number of pages	6
Journal	International Journal of Tuberculosis and Lung Disease
Volume	19
Issue number	5
DOIs	https://doi.org/10.5588/ijtld.14.0636
Publication status	Published - 2015 May 1

Keywords

Latent tuberculous infection
Quanti-FERON test
TB outbreaks
Tuberculin skin test

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5588/ijtld.14.0636

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@article{37dace532357431c9e7878cc6d5d045c,

title = "Role of confirmatory interferon-gamma release assays in school outbreaks of tuberculosis in South Korea",

abstract = "OBJECTIVE: To investigate the usefulness of confirmatory QuantiFERON{\textregistered} (QFT) testing among tuberculin skin test (TST) positive contacts to diagnose latent tuberculous infection (LTBI) in tuberculosis (TB) outbreaks among adolescents. DESIGN: We used the Korean national claims database to identify the development of active TB disease in relation to initial TST (cut-off 10 mm induration) and subsequent QFT results. RESULTS: A total of 7475 contacts in 89 schools were divided into four groups: TST-(n = 5714), TST+/QFT+(n = 534), TST+/QFT- (n = 697) and TST+ only (n = 530). The mean duration of follow-up was 3.9 ± 0.9 years. For contacts with no LTBI treatment (n = 6868), TB incidence rates per 1000 person-years (py) and the adjusted hazard ratio (HR) compared with TST-individuals were as follows: TST+/QFT+, 66.2/1000 py (HR 35.59, 95%CI 14.03-90.31, P < 0.001); TST+ only, 10.1/1000 py (HR 5.16, 95%CI 2.91-9.17, P < 0.001); TST+/QFT-, 4.0/1000 py (HR 2.05, 95%CI 1.05-4.01, P = 0.035); and TST- 2.0/1000 py. The TB progression rate was significantly higher in TST+/QFT+ than in TST+/QFT-individuals (HR 16.82, 95 CI 5.84-48.46, P < 0.001). CONCLUSION: A confirmatory QFT for TST+contacts could reduce the number of candidates for LTBI treatment after school TB outbreaks.",

keywords = "Latent tuberculous infection, Quanti-FERON test, TB outbreaks, Tuberculin skin test",

author = "Kim, {H. J.} and Lee, {G. H.} and S. Ryoo and Oh, {S. Y.} and Lee, {J. B.} and Kim, {J. H.} and C. Shin and Lee, {Seung Heon}",

note = "Publisher Copyright: {\textcopyright} 2015 The Union.",

year = "2015",

month = may,

day = "1",

doi = "10.5588/ijtld.14.0636",

language = "English",

volume = "19",

pages = "576--581",

journal = "International Journal of Tuberculosis and Lung Disease",

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publisher = "International Union against Tubercul. and Lung Dis.",

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T1 - Role of confirmatory interferon-gamma release assays in school outbreaks of tuberculosis in South Korea

AU - Kim, H. J.

AU - Lee, G. H.

AU - Ryoo, S.

AU - Oh, S. Y.

AU - Lee, J. B.

AU - Kim, J. H.

AU - Shin, C.

AU - Lee, Seung Heon

PY - 2015/5/1

Y1 - 2015/5/1

N2 - OBJECTIVE: To investigate the usefulness of confirmatory QuantiFERON® (QFT) testing among tuberculin skin test (TST) positive contacts to diagnose latent tuberculous infection (LTBI) in tuberculosis (TB) outbreaks among adolescents. DESIGN: We used the Korean national claims database to identify the development of active TB disease in relation to initial TST (cut-off 10 mm induration) and subsequent QFT results. RESULTS: A total of 7475 contacts in 89 schools were divided into four groups: TST-(n = 5714), TST+/QFT+(n = 534), TST+/QFT- (n = 697) and TST+ only (n = 530). The mean duration of follow-up was 3.9 ± 0.9 years. For contacts with no LTBI treatment (n = 6868), TB incidence rates per 1000 person-years (py) and the adjusted hazard ratio (HR) compared with TST-individuals were as follows: TST+/QFT+, 66.2/1000 py (HR 35.59, 95%CI 14.03-90.31, P < 0.001); TST+ only, 10.1/1000 py (HR 5.16, 95%CI 2.91-9.17, P < 0.001); TST+/QFT-, 4.0/1000 py (HR 2.05, 95%CI 1.05-4.01, P = 0.035); and TST- 2.0/1000 py. The TB progression rate was significantly higher in TST+/QFT+ than in TST+/QFT-individuals (HR 16.82, 95 CI 5.84-48.46, P < 0.001). CONCLUSION: A confirmatory QFT for TST+contacts could reduce the number of candidates for LTBI treatment after school TB outbreaks.

AB - OBJECTIVE: To investigate the usefulness of confirmatory QuantiFERON® (QFT) testing among tuberculin skin test (TST) positive contacts to diagnose latent tuberculous infection (LTBI) in tuberculosis (TB) outbreaks among adolescents. DESIGN: We used the Korean national claims database to identify the development of active TB disease in relation to initial TST (cut-off 10 mm induration) and subsequent QFT results. RESULTS: A total of 7475 contacts in 89 schools were divided into four groups: TST-(n = 5714), TST+/QFT+(n = 534), TST+/QFT- (n = 697) and TST+ only (n = 530). The mean duration of follow-up was 3.9 ± 0.9 years. For contacts with no LTBI treatment (n = 6868), TB incidence rates per 1000 person-years (py) and the adjusted hazard ratio (HR) compared with TST-individuals were as follows: TST+/QFT+, 66.2/1000 py (HR 35.59, 95%CI 14.03-90.31, P < 0.001); TST+ only, 10.1/1000 py (HR 5.16, 95%CI 2.91-9.17, P < 0.001); TST+/QFT-, 4.0/1000 py (HR 2.05, 95%CI 1.05-4.01, P = 0.035); and TST- 2.0/1000 py. The TB progression rate was significantly higher in TST+/QFT+ than in TST+/QFT-individuals (HR 16.82, 95 CI 5.84-48.46, P < 0.001). CONCLUSION: A confirmatory QFT for TST+contacts could reduce the number of candidates for LTBI treatment after school TB outbreaks.

KW - Latent tuberculous infection

KW - Quanti-FERON test

KW - TB outbreaks

KW - Tuberculin skin test

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SN - 1027-3719

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JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

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ER -

Role of confirmatory interferon-gamma release assays in school outbreaks of tuberculosis in South Korea

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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