Role of CRTC2 in metabolic homeostasis: Key regulator of whole-body energy metabolism?

Hye Sook Han, Yongmin Kwon, Seung Hoi Koo

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)


Cyclic adenosine monophosphate (cAMP) signaling is critical for regulating metabolic homeostasis in mammals. In particular, transcriptional regulation by cAMP response element-binding protein (CREB) and its coactivator, CREB-regulated transcription coactivator (CRTC), is essential for controlling the expression of critical enzymes in the metabolic process, leading to more chronic changes in metabolic flux. Among the CRTC isoforms, CRTC2 is predominantly expressed in peripheral tissues and has been shown to be associated with various metabolic pathways in tissue-specific manners. While initial reports showed the physiological role of CRTC2 in regulating gluconeogenesis in the liver, recent studies have further delineated the role of this transcriptional coactivator in the regulation of glucose and lipid metabolism in various tissues, including the liver, pancreatic islets, endocrine tissues of the small intestines, and adipose tissues. In this review, we discuss recent studies that have utilized knockout mouse models to delineate the role of CRTC2 in the regulation of metabolic homeostasis.

Original languageEnglish
Article number0200
JournalDiabetes and Metabolism Journal
Publication statusPublished - 2020

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea Grant funded by the Korean Government (MSIT) (NRF-2018R1A2B3001540, NRF-2015R1A5A1009024, and NRF-2019M3A9D5A01102794).

Publisher Copyright:
© 2020


  • CRTC2 protein
  • Crtc2 protein
  • Cyclic AMP
  • Energy metabolism
  • Genetic
  • Human
  • Mouse
  • Transcription

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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