Role of microrna and oxidative stress in influenza a virus pathogenesis

Md Mamunul Haque, Dhiraj P. Murale, Jun Seok Lee

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)


MicroRNAs (miRNAs) are non‐coding RNAs that regulate diverse cellular pathways by controlling gene expression. Increasing evidence has revealed their critical involvement in influenza A virus (IAV) pathogenesis. Host–IAV interactions induce different levels of oxidative stress (OS) by disrupting the balance between reactive oxygen species (ROS) and antioxidant factors. It is thought that miRNA may regulate the expression of ROS; conversely, ROS can induce or suppress miRNA expression during IAV infection. Thus, miRNA and OS are the two key factors of IAV infection and pathogenesis. Accordingly, interactions between OS and miRNA during IAV infection might be a critical area for further research. In this review, we discuss the crosstalk between miRNAs and OS during IAV infection. Additionally, we highlight the potential of miRNAs as diagnostic markers and therapeutic targets for IAV infections. This knowledge will help us to study host–virus interactions with novel intervention strategies.

Original languageEnglish
Article number8962
Pages (from-to)1-11
Number of pages11
JournalInternational journal of molecular sciences
Issue number23
Publication statusPublished - 2020 Dec 1
Externally publishedYes

Bibliographical note

Funding Information:
Funding: This work was supported by the National Research Foundation funded by the Ministry of Science, ICT and Future Planning (NRF‐2018M3A9H4079286, NRF‐2020R1A2C2004422), and KIST intramural funding (2E30480). Dr. Haque is a recipient of the Korea Research Fellowship Program through the National Research Foundation of Korea (NRF) (NRF‐2018H1D3A1A02074556).

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.


  • Influenza A virus
  • MicroRNA
  • Oxidative stress

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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