Abstract
The α9α10 nicotinic acetylcholine receptors (nAChRs) mediates efferent inhibition of hair cell function within the auditory sensory organ. Gating of the nAChRs leads to activation of calcium-dependent potassium channels to hyperpolarize the hair cell. In efferent system, main calcium providers to SK channel are nAChR and synaptic cistern, which contribution to efferent inhibition is different between avian and mammalian species. Calcium permeation is more effective in nAChRs of mammalian cochlea than avian cochlea, and mammalian calcium permeability of nAChRs is about 3 times more than avian hair cell. Thus, mammalian nAChRs is a main component of efferent inhibition in cochlear hair cell system
| Original language | English |
|---|---|
| Pages (from-to) | 108-113 |
| Number of pages | 6 |
| Journal | Korean Journal of Audiology |
| Volume | 16 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2012 Dec |
| Externally published | Yes |
Keywords
- Acetylcholine
- Calcium
- Cochlea
- Hair cell
- Nicotinic receptor
ASJC Scopus subject areas
- Sensory Systems
- Speech and Hearing