Role of oxidative stress in epileptic seizures

Eun Joo Shin, Ji Hoon Jeong, Yoon Hee Chung, Won Ki Kim, Kwang Ho Ko, Jae Hyung Bach, Jau Shyong Hong, Yukio Yoneda, Hyoung Chun Kim

Research output: Contribution to journalShort surveypeer-review

324 Citations (Scopus)


Oxidative stress resulting from excessive free-radical release is likely implicated in the initiation and progression of epilepsy. Therefore, antioxidant therapies aimed at reducing oxidative stress have received considerable attention in epilepsy treatment. However, much evidence suggests that oxidative stress does not always have the same pattern in all seizures models. Thus, this review provides an overview aimed at achieving a better understanding of this issue. We summarize work regarding seizure models (i.e.; genetic rat models, kainic acid, pilocarpine, pentylenetetrazol, and trimethyltin), oxidative stress as an etiologic factor in epileptic seizures (i.e.; impairment of antioxidant systems, mitochondrial dysfunction, involvement of redox-active metals, arachidonic acid pathway activation, and aging), and antioxidant strategies for seizure treatment. Combined, this review highlights pharmacological mechanisms associated with oxidative stress in epileptic seizures and the potential for neuroprotection in epilepsy that targets oxidative stress and is supported by effective antioxidant treatment.

Original languageEnglish
Pages (from-to)122-137
Number of pages16
JournalNeurochemistry International
Issue number2
Publication statusPublished - 2011 Aug

Bibliographical note

Funding Information:
This study was supported by a grant #2011K000271 from the Brain Research Center from 21st Century Frontier Research Program funded by the Ministry of Science and Technology, Republic of Korea . Jae-Hyung Bach was supported by BK 21 program.


  • Animal models
  • Antioxidant strategies
  • Epileptic seizures
  • Oxidative stress

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology


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