Role of protein kinase C δ in an early stage of coxsackievirus-B3-induced apoptosis in HeLa cells

Jung Hyun Park; Du Hyong Cho; Cheol Won Yun; Jae Won Soh; Young Mee Jee; Sang Ick Park; Inho Jo; Jae Hwan Nam

Role of protein kinase C δ in an early stage of coxsackievirus-B3-induced apoptosis in HeLa cells

Jung Hyun Park, Du Hyong Cho, Cheol Won Yun, Jae Won Soh, Young Mee Jee, Sang Ick Park, Inho Jo, Jae Hwan Nam

Research output: Contribution to journal › Article › peer-review

Abstract

CVB3 is a virulent human pathogen that induces myocarditis and ultimately dilated cardiomyopathy. Although several apoptotic factors are involved in the cell death induced by CVB3, the upstream signal transduction factors of CVB3-induced apoptosis are still unclear. We explored and characterized the role of PKC δ in CVB3-infected cells. PKC δ was cleaved after CVB3 infection and was activated at 6 h postinfection. PKC δ was also translocated into the nucleus via mitochondria after CVB3 infection, and overexpression of wild-type PKC δ reduced the apoptotic cell death caused by CVB3. These results indicate that PKC δ has an anti-apoptotic role in CVB3 infection.

Original language	English
Pages (from-to)	550-555
Number of pages	6
Journal	Journal of microbiology and biotechnology
Volume	16
Issue number	4
Publication status	Published - 2006 Apr

Keywords

Apoptosis
CVB3
PKC δ

ASJC Scopus subject areas

Biotechnology
Applied Microbiology and Biotechnology

Cite this

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title = "Role of protein kinase C δ in an early stage of coxsackievirus-B3-induced apoptosis in HeLa cells",

abstract = "CVB3 is a virulent human pathogen that induces myocarditis and ultimately dilated cardiomyopathy. Although several apoptotic factors are involved in the cell death induced by CVB3, the upstream signal transduction factors of CVB3-induced apoptosis are still unclear. We explored and characterized the role of PKC δ in CVB3-infected cells. PKC δ was cleaved after CVB3 infection and was activated at 6 h postinfection. PKC δ was also translocated into the nucleus via mitochondria after CVB3 infection, and overexpression of wild-type PKC δ reduced the apoptotic cell death caused by CVB3. These results indicate that PKC δ has an anti-apoptotic role in CVB3 infection.",

keywords = "Apoptosis, CVB3, PKC δ",

author = "Park, {Jung Hyun} and Cho, {Du Hyong} and Yun, {Cheol Won} and Soh, {Jae Won} and Jee, {Young Mee} and Park, {Sang Ick} and Inho Jo and Nam, {Jae Hwan}",

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T1 - Role of protein kinase C δ in an early stage of coxsackievirus-B3-induced apoptosis in HeLa cells

AU - Park, Jung Hyun

AU - Cho, Du Hyong

AU - Yun, Cheol Won

AU - Soh, Jae Won

AU - Jee, Young Mee

AU - Park, Sang Ick

AU - Jo, Inho

AU - Nam, Jae Hwan

PY - 2006/4

Y1 - 2006/4

N2 - CVB3 is a virulent human pathogen that induces myocarditis and ultimately dilated cardiomyopathy. Although several apoptotic factors are involved in the cell death induced by CVB3, the upstream signal transduction factors of CVB3-induced apoptosis are still unclear. We explored and characterized the role of PKC δ in CVB3-infected cells. PKC δ was cleaved after CVB3 infection and was activated at 6 h postinfection. PKC δ was also translocated into the nucleus via mitochondria after CVB3 infection, and overexpression of wild-type PKC δ reduced the apoptotic cell death caused by CVB3. These results indicate that PKC δ has an anti-apoptotic role in CVB3 infection.

AB - CVB3 is a virulent human pathogen that induces myocarditis and ultimately dilated cardiomyopathy. Although several apoptotic factors are involved in the cell death induced by CVB3, the upstream signal transduction factors of CVB3-induced apoptosis are still unclear. We explored and characterized the role of PKC δ in CVB3-infected cells. PKC δ was cleaved after CVB3 infection and was activated at 6 h postinfection. PKC δ was also translocated into the nucleus via mitochondria after CVB3 infection, and overexpression of wild-type PKC δ reduced the apoptotic cell death caused by CVB3. These results indicate that PKC δ has an anti-apoptotic role in CVB3 infection.

KW - Apoptosis

KW - CVB3

KW - PKC δ

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M3 - Article

AN - SCOPUS:33646582945

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JF - Journal of microbiology and biotechnology

IS - 4

ER -

Role of protein kinase C δ in an early stage of coxsackievirus-B3-induced apoptosis in HeLa cells

Abstract

Keywords

ASJC Scopus subject areas

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