Role of surgery in the management of anaplastic thyroid carcinoma: Korean nationwide multicenter study of 329 patients with anaplastic thyroid carcinoma, 2000 to 2012

Seung Kuk Baek; Myung Chul Lee; J. Hun Hah; Soon Hyun Ahn; Young Ik Son; Young Soo Rho; Phil Sang Chung; Yoon Se Lee; Bon Seok Koo; Kwang Yoon Jung; Byung Joo Lee

doi:10.1002/hed.24559

Role of surgery in the management of anaplastic thyroid carcinoma: Korean nationwide multicenter study of 329 patients with anaplastic thyroid carcinoma, 2000 to 2012

Seung Kuk Baek, Myung Chul Lee, J. Hun Hah, Soon Hyun Ahn, Young Ik Son, Young Soo Rho, Phil Sang Chung, Yoon Se Lee, Bon Seok Koo, Kwang Yoon Jung, Byung Joo Lee

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Background: The Korean Society of Thyroid Head and Neck Surgery established a nationwide multicenter registry of anaplastic thyroid carcinoma (ATC) and evaluated the prognostic factors and treatment outcomes of ATC. Methods: The present study enrolled 329 patients who were diagnosed with ATC between January 2000 and December 2012 at 19 medical centers in Korea. Survival outcomes were evaluated according to various clinical factors and treatments. Results: Multivariate analysis identified age ≥70 years old, the presence of initial clinical symptoms, distant metastasis, and treatment modality as significant risk factors (p <.05). The patients who underwent curative resection and adjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CRT) showed the best survival on multivariate analysis (p < 0.05). Conclusion: Although ATC is a lethal neoplasm, long-term survival may be acquired in cases in which the aggressive management, including curative resection or RT/concurrent CRT, is possible for therapeutic intent.

Original language	English
Pages (from-to)	133-139
Number of pages	7
Journal	Head and Neck
Volume	39
Issue number	1
DOIs	https://doi.org/10.1002/hed.24559
Publication status	Published - 2017 Jan 1

Bibliographical note

Publisher Copyright:
© 2016 Wiley Periodicals, Inc.

Keywords

anaplastic thyroid carcinoma
multicenter study
multimodal treatment
prognostic factor
surgery

ASJC Scopus subject areas

Otorhinolaryngology

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Baek, S. K., Lee, M. C., Hah, J. H., Ahn, S. H., Son, Y. I., Rho, Y. S., Chung, P. S., Lee, Y. S., Koo, B. S., Jung, K. Y., & Lee, B. J. (2017). Role of surgery in the management of anaplastic thyroid carcinoma: Korean nationwide multicenter study of 329 patients with anaplastic thyroid carcinoma, 2000 to 2012. Head and Neck, 39(1), 133-139. https://doi.org/10.1002/hed.24559

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abstract = "Background: The Korean Society of Thyroid Head and Neck Surgery established a nationwide multicenter registry of anaplastic thyroid carcinoma (ATC) and evaluated the prognostic factors and treatment outcomes of ATC. Methods: The present study enrolled 329 patients who were diagnosed with ATC between January 2000 and December 2012 at 19 medical centers in Korea. Survival outcomes were evaluated according to various clinical factors and treatments. Results: Multivariate analysis identified age ≥70 years old, the presence of initial clinical symptoms, distant metastasis, and treatment modality as significant risk factors (p <.05). The patients who underwent curative resection and adjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CRT) showed the best survival on multivariate analysis (p < 0.05). Conclusion: Although ATC is a lethal neoplasm, long-term survival may be acquired in cases in which the aggressive management, including curative resection or RT/concurrent CRT, is possible for therapeutic intent.",

keywords = "anaplastic thyroid carcinoma, multicenter study, multimodal treatment, prognostic factor, surgery",

author = "Baek, {Seung Kuk} and Lee, {Myung Chul} and Hah, {J. Hun} and Ahn, {Soon Hyun} and Son, {Young Ik} and Rho, {Young Soo} and Chung, {Phil Sang} and Lee, {Yoon Se} and Koo, {Bon Seok} and Jung, {Kwang Yoon} and Lee, {Byung Joo}",

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year = "2017",

month = jan,

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doi = "10.1002/hed.24559",

language = "English",

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AU - Baek, Seung Kuk

AU - Lee, Myung Chul

AU - Hah, J. Hun

AU - Ahn, Soon Hyun

AU - Son, Young Ik

AU - Rho, Young Soo

AU - Chung, Phil Sang

AU - Lee, Yoon Se

AU - Koo, Bon Seok

AU - Jung, Kwang Yoon

AU - Lee, Byung Joo

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AB - Background: The Korean Society of Thyroid Head and Neck Surgery established a nationwide multicenter registry of anaplastic thyroid carcinoma (ATC) and evaluated the prognostic factors and treatment outcomes of ATC. Methods: The present study enrolled 329 patients who were diagnosed with ATC between January 2000 and December 2012 at 19 medical centers in Korea. Survival outcomes were evaluated according to various clinical factors and treatments. Results: Multivariate analysis identified age ≥70 years old, the presence of initial clinical symptoms, distant metastasis, and treatment modality as significant risk factors (p <.05). The patients who underwent curative resection and adjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CRT) showed the best survival on multivariate analysis (p < 0.05). Conclusion: Although ATC is a lethal neoplasm, long-term survival may be acquired in cases in which the aggressive management, including curative resection or RT/concurrent CRT, is possible for therapeutic intent.

KW - anaplastic thyroid carcinoma

KW - multicenter study

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Role of surgery in the management of anaplastic thyroid carcinoma: Korean nationwide multicenter study of 329 patients with anaplastic thyroid carcinoma, 2000 to 2012

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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