Glucose homeostasis is tightly controlled by the regulation of glucose production in the liver and glucose uptake into peripheral tissues, such as skeletal muscle and adipose tissue. Under prolonged fasting, hepatic gluconeogenesis is mainly responsible for glucose production in the liver, which is essential for tissues, organs, and cells, such as skeletal muscle, the brain, and red blood cells. Hepatic gluconeogenesis is controlled in part by the concerted actions of transcriptional regulators. Fasting signals are relayed by various intracellular enzymes, such as kinases, phosphatases, acetyltransferases, and deacetylases, which affect the transcriptional activity of transcription factors and transcriptional coactivators for gluconeogenic genes. Protein arginine methyltransferases (PRMTs) were recently added to the list of enzymes that are critical for regulating transcription in hepatic gluconeogenesis. In this review, we briefly discuss general aspects of PRMTs in the control of transcription. More specifically, we summarize the roles of four PRMTs: PRMT1, PRMT 4, PRMT 5, and PRMT 6, in the control of hepatic gluconeogenesis through specific regulation of FoxO1- and CREB-dependent transcriptional events.
Bibliographical noteFunding Information:
This work was supported by the National Research Foundation of Korea (grant No. NRF-2010-0015098 and NRF-2012 M3A9B6055345), funded by the Ministry of Science, ICT & Future Planning, Republic of Korea, and by grants from the Korean Health Technology R&D Project (grant No. A111345 and HI13C1886), funded by the Ministry of Health and Welfare, Republic of Korea.
© 2014 Korean Endocrine Society.
- Glucose metabolism
- Protein-arginine N-methyltransferases
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism