Romo1 is associated with ROS production and cellular growth in human gliomas

Mi Ok Yu, Na Hyun Song, Kyung-Jae Park, Dong-Hyuk Park, Se Hyuk Kim, Yang Seok Chae, Yong Gu Chung, Sung Gil Chi, Shin-Hyuk Kang

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Romo1 is a mitochondrial protein whose elevated expression is commonly observed in various types of human cancers. However, the expression status of Romo1 and its implication in the pathogenesis of human glioblastoma (GBM) remain largely undefined. To understand the role of Romo1 in the progression of GBM, we explored its expression in a series of GBM tissues and cell lines and determined its effect on ROS production, cell proliferation, and tumor growth. Romo1 was frequently overexpressed at the mRNA level in both primary tumors and cell lines and its elevation was more commonly observed in high grade tumors versus low grade tumors. Romo1 expression was associated with ROS production and its knockdown led to a marked reduction of in vitro cellular growth and anchorage-independent growth of GBM. Consistently, Romo1 depletion induced a G2/M arrest of the cell cycle that was accompanied with accumulation of phospho-cdc2. Furthermore, a mouse xenograft assay revealed that Romo1 depletion significantly decreased tumor formation and growth. Therefore, our data demonstrate that Romo1 upregulation is a common event in human GBMs and contributes to the malignant tumor progression, suggesting that Romo1 could be a new therapeutic target for human GBM.

Original languageEnglish
Pages (from-to)73-81
Number of pages9
JournalJournal of Neuro-Oncology
Issue number1
Publication statusPublished - 2015 Jan

Bibliographical note

Funding Information:
This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2010-0009959).

Publisher Copyright:
© 2014, Springer Science+Business Media New York.


  • Glioma
  • Reactive oxygen species
  • Romo1
  • Tumorigenicity

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research


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