Abstract
We conducted a 16-week double-blind randomized controlled single-center trial to evaluate the safety and efficacy of dermal rice bran supercritical CO2 extract (RB-SCE) in the treatment of androgenic alopecia. Fifty alopecia patients were randomly assigned to the experimental and placebo groups. The experimental group received a dermal application of 0.5% RB-SCE (8 mL/d) to the head skin for 16 weeks while the control group received a dermal application of placebo. Changes in hair count, diameter, and density were evaluated with a Folliscope®. Patient satisfaction was evaluated via questionnaire and clinical photographs were rated by dermatologists. The results showed that RB-SCE significantly increased hair density and hair diameter in male subjects. Patient satisfaction and the evaluation of photographs by dermatologists also confirmed the effectiveness of RB-SCE in the treatment of alopecia. No adverse reactions related to RB-SCE were reported. Therefore, RB-SCE shows promise for use in functional cosmetics and pharmaceuticals.
Original language | English |
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Pages (from-to) | 1856-1863 |
Number of pages | 8 |
Journal | Biological and Pharmaceutical Bulletin |
Volume | 38 |
Issue number | 12 |
DOIs | |
Publication status | Published - 2015 Dec 1 |
Bibliographical note
Publisher Copyright:© 2015 The Pharmaceutical Society of Japan.
Keywords
- Alopecia
- Clinical study
- Hair growth-promoting activity
- Rice bran supercritical CO extract
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science