Safety of ultra-rapid intravenous infusion of hepatitis B immunoglobulin in liver transplant recipients

S. Hwang, Y. D. Yu, G. C. Park, Y. I. Choi, P. J. Park, S. W. Jung, J. M. Namgoong, S. Y. Yoon, H. S. Ha, J. J. Hong, I. O. Kim, M. K. Jeon, J. E. Ma, S. Y. Choi, J. S. Yun, D. H. Jung, G. W. Song, T. Y. Ha, D. B. Moon, K. H. KimyC. S. Ahn, S. G. Lee

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Purpose: To evaluate the safety of institutional protocol for ultra-rapid hepatitis B immunoglobulin (HBIG) infusion (10,000 IU in 30 minutes) for hepatitis B virus prophylaxis in adult liver transplant recipients. Methods: In this case-controlled study, prospectively recruited liver transplant recipients received ultra-rapid infusions of HBIG (10,000 units in 30 minutes) for 6 months. The historical control group consisted of patients who had received 1-hour HBIG infusions (conventional rapid infusion) for the precedent 6 months. Results: We found that 1472 patients had received 5744 ultra-rapid HBIG infusions, whereas 1343 patients had received 5200 conventional rapid HBIG infusions. Adverse side-effects were observed after 7 (0.13%) and 9 (0.16%) infusions, respectively (P = .763). The number of infusions per month increased significantly, from 878 ± 34 before the introduction of ultra-rapid infusion to 957 ± 29 afterwards (P < .001), an increase of 10.5%. The maximal capacity of HBIG infusions per day in the outpatient clinic increased from 53 for conventional rapid infusion to 65 for ultra-rapid infusion, without expansion of the outpatient facility or equipment. Conclusions: Nearly all adult liver recipients able to tolerate 1-hour infusions of HBIG can also tolerate ultra-rapid infusions well. Thus, it seems to be reasonable to perform ultra-rapid infusion protocol widely for patient convenience.

Original languageEnglish
Pages (from-to)1780-1782
Number of pages3
JournalTransplantation Proceedings
Issue number5
Publication statusPublished - 2011 Jun
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Transplantation


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