Saponin-based nanoemulsification improves the antioxidant properties of vitamin A and E in AML-12 cells

Qaisra Naheed Choudhry; Mi Jeong Kim; Tae Gyun Kim; Jeong Hoon Pan; Jun Ho Kim; Sung Jin Park; Jin Hyup Lee; Young Jun Kim

doi:10.3390/ijms17091406

Saponin-based nanoemulsification improves the antioxidant properties of vitamin A and E in AML-12 cells

Qaisra Naheed Choudhry
, Mi Jeong Kim
, Tae Gyun Kim
, Jeong Hoon Pan
, Jun Ho Kim
, Sung Jin Park
, Jin Hyup Lee
, Young Jun Kim^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Our work aimed to investigate the protective effects of saponin-based nanoemulsions of vitamin A and E against oxidative stress-induced cellular damage in AML-12 cells. Saponin nanoemulsions of vitamin A (SAN) and vitamin E (SEN) were prepared by high-pressure homogenization and characterized in terms of size, zeta potential, and polydispersity index. SEN and SAN protect AML-12 cells against oxidative stress-induced cellular damage more efficiently via scavenging reactive oxygen species (ROS), and reducing DNA damage, protein carbonylation, and lipid peroxidation. These results provide valuable information for the development of nanoemulsion-based delivery systems that would improve the antioxidant properties of vitamin A and E.

Original language	English
Article number	1406
Journal	International journal of molecular sciences
Volume	17
Issue number	9
DOIs	https://doi.org/10.3390/ijms17091406
Publication status	Published - 2016 Sept

Bibliographical note

Publisher Copyright:
© 2016 by the authors; licensee MDPI, Basel, Switzerland.

Keywords

Antioxidant capacity
Nanoemulsification
Saponin
Vitamin A
Vitamin E

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.3390/ijms17091406

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title = "Saponin-based nanoemulsification improves the antioxidant properties of vitamin A and E in AML-12 cells",

abstract = "Our work aimed to investigate the protective effects of saponin-based nanoemulsions of vitamin A and E against oxidative stress-induced cellular damage in AML-12 cells. Saponin nanoemulsions of vitamin A (SAN) and vitamin E (SEN) were prepared by high-pressure homogenization and characterized in terms of size, zeta potential, and polydispersity index. SEN and SAN protect AML-12 cells against oxidative stress-induced cellular damage more efficiently via scavenging reactive oxygen species (ROS), and reducing DNA damage, protein carbonylation, and lipid peroxidation. These results provide valuable information for the development of nanoemulsion-based delivery systems that would improve the antioxidant properties of vitamin A and E.",

keywords = "Antioxidant capacity, Nanoemulsification, Saponin, Vitamin A, Vitamin E",

author = "Choudhry, \{Qaisra Naheed\} and Kim, \{Mi Jeong\} and Kim, \{Tae Gyun\} and Pan, \{Jeong Hoon\} and Kim, \{Jun Ho\} and Park, \{Sung Jin\} and Lee, \{Jin Hyup\} and Kim, \{Young Jun\}",

note = "Publisher Copyright: {\textcopyright} 2016 by the authors; licensee MDPI, Basel, Switzerland.",

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month = sep,

doi = "10.3390/ijms17091406",

language = "English",

volume = "17",

journal = "International journal of molecular sciences",

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T1 - Saponin-based nanoemulsification improves the antioxidant properties of vitamin A and E in AML-12 cells

AU - Choudhry, Qaisra Naheed

AU - Kim, Mi Jeong

AU - Kim, Tae Gyun

AU - Pan, Jeong Hoon

AU - Kim, Jun Ho

AU - Park, Sung Jin

AU - Lee, Jin Hyup

AU - Kim, Young Jun

PY - 2016/9

Y1 - 2016/9

N2 - Our work aimed to investigate the protective effects of saponin-based nanoemulsions of vitamin A and E against oxidative stress-induced cellular damage in AML-12 cells. Saponin nanoemulsions of vitamin A (SAN) and vitamin E (SEN) were prepared by high-pressure homogenization and characterized in terms of size, zeta potential, and polydispersity index. SEN and SAN protect AML-12 cells against oxidative stress-induced cellular damage more efficiently via scavenging reactive oxygen species (ROS), and reducing DNA damage, protein carbonylation, and lipid peroxidation. These results provide valuable information for the development of nanoemulsion-based delivery systems that would improve the antioxidant properties of vitamin A and E.

AB - Our work aimed to investigate the protective effects of saponin-based nanoemulsions of vitamin A and E against oxidative stress-induced cellular damage in AML-12 cells. Saponin nanoemulsions of vitamin A (SAN) and vitamin E (SEN) were prepared by high-pressure homogenization and characterized in terms of size, zeta potential, and polydispersity index. SEN and SAN protect AML-12 cells against oxidative stress-induced cellular damage more efficiently via scavenging reactive oxygen species (ROS), and reducing DNA damage, protein carbonylation, and lipid peroxidation. These results provide valuable information for the development of nanoemulsion-based delivery systems that would improve the antioxidant properties of vitamin A and E.

KW - Antioxidant capacity

KW - Nanoemulsification

KW - Saponin

KW - Vitamin A

KW - Vitamin E

UR - https://www.scopus.com/pages/publications/84984831760

U2 - 10.3390/ijms17091406

DO - 10.3390/ijms17091406

M3 - Article

C2 - 27571071

AN - SCOPUS:84984831760

SN - 1661-6596

VL - 17

JO - International journal of molecular sciences

JF - International journal of molecular sciences

IS - 9

M1 - 1406

ER -

Saponin-based nanoemulsification improves the antioxidant properties of vitamin A and E in AML-12 cells

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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