Abstract
With global expansion of the COVID-19 pandemic and the emergence of new variants, extensive efforts have been made to develop highly effective antiviral drugs and vaccines against SARS-CoV-2. The interactions of coronaviruses with host antiviral interferon pathways ultimately determine successful viral replication and SARS-CoV-2-induced pathogenesis. Innate immune receptors play an essential role in host defense against SARS-CoV-2 via the induction of IFN production and signaling. Here, we summarize the recent advances in innate immune sensing mechanisms of SARS-CoV-2 and various strategies by which SARS-CoV-2 antagonizes antiviral innate immune signaling pathways, with a particular focus on mechanisms utilized by multiple SARS-CoV-2 proteins to evade interferon induction and signaling in host cell. Understanding the underlying immune evasion mechanisms of SARS-CoV-2 is essential for the improvement of vaccines and therapeutic strategies.
Original language | English |
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Pages (from-to) | 290-299 |
Number of pages | 10 |
Journal | Journal of Microbiology |
Volume | 60 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2022 Mar |
Externally published | Yes |
Keywords
- COVID-19
- SARS-CoV-2
- immunity
- interferon
ASJC Scopus subject areas
- Microbiology
- Applied Microbiology and Biotechnology