SARS-CoV-2-mediated evasion strategies for antiviral interferon pathways

Soo Jin Oh; Ok Sarah Shin

doi:10.1007/s12275-022-1525-1

SARS-CoV-2-mediated evasion strategies for antiviral interferon pathways

Soo Jin Oh, Ok Sarah Shin

Research output: Contribution to journal › Review article › peer-review

16 Citations (Scopus)

Abstract

With global expansion of the COVID-19 pandemic and the emergence of new variants, extensive efforts have been made to develop highly effective antiviral drugs and vaccines against SARS-CoV-2. The interactions of coronaviruses with host antiviral interferon pathways ultimately determine successful viral replication and SARS-CoV-2-induced pathogenesis. Innate immune receptors play an essential role in host defense against SARS-CoV-2 via the induction of IFN production and signaling. Here, we summarize the recent advances in innate immune sensing mechanisms of SARS-CoV-2 and various strategies by which SARS-CoV-2 antagonizes antiviral innate immune signaling pathways, with a particular focus on mechanisms utilized by multiple SARS-CoV-2 proteins to evade interferon induction and signaling in host cell. Understanding the underlying immune evasion mechanisms of SARS-CoV-2 is essential for the improvement of vaccines and therapeutic strategies.

Original language	English
Pages (from-to)	290-299
Number of pages	10
Journal	Journal of Microbiology
Volume	60
Issue number	3
DOIs	https://doi.org/10.1007/s12275-022-1525-1
Publication status	Published - 2022 Mar
Externally published	Yes

Bibliographical note

Funding Information:
We thank Paz Altamirano, Anya Deubel, Krystina Mainz, Anja Pachenkova and Carolina Stönner for their support when conducting the study. We further thank Shalom Schwartz for kindly providing us with the translations of the Portrait Values Questionnaire. CM is grateful for the Klaus Murmann Scholarship awarded by the Stiftung der Deutschen Wirtschaft. We acknowledge support by the Open Access Publication Fund of the Freie Universität Berlin.

Funding Information:
This research was funded by the Basic Science Research Program of the National Research Foundation of Korea (NRF) by the Ministry of Science, ICT & Future Planning (NRF-2019R1A2C1005961), and Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI21C1252).

Publisher Copyright:
© 2022, The Microbiological Society of Korea.

Keywords

COVID-19
SARS-CoV-2
immunity
interferon

ASJC Scopus subject areas

Microbiology
Applied Microbiology and Biotechnology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s12275-022-1525-1

Cite this

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abstract = "With global expansion of the COVID-19 pandemic and the emergence of new variants, extensive efforts have been made to develop highly effective antiviral drugs and vaccines against SARS-CoV-2. The interactions of coronaviruses with host antiviral interferon pathways ultimately determine successful viral replication and SARS-CoV-2-induced pathogenesis. Innate immune receptors play an essential role in host defense against SARS-CoV-2 via the induction of IFN production and signaling. Here, we summarize the recent advances in innate immune sensing mechanisms of SARS-CoV-2 and various strategies by which SARS-CoV-2 antagonizes antiviral innate immune signaling pathways, with a particular focus on mechanisms utilized by multiple SARS-CoV-2 proteins to evade interferon induction and signaling in host cell. Understanding the underlying immune evasion mechanisms of SARS-CoV-2 is essential for the improvement of vaccines and therapeutic strategies.",

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SARS-CoV-2-mediated evasion strategies for antiviral interferon pathways

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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