Satisfaction of patients and caregivers with long-acting injectable risperidone and oral atypical antipsychotics

Changsu Han, Bun Hee Lee, Yong Ku Kim, Heon Jeong Lee, Seung Hyun Kim, Leen Kim, Min Soo Lee, Sook Haeng Joe, Byung Joo Ham, In Kwa Jung

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Background: The satisfaction of schizophrenia patients with their treatment can strongly influence treatment adherence and subsequent long-term outcome. Atypical antipsychotics reportedly have greater adherence rates, owing to a lower incidence of side effects and higher levels of patient satisfaction and acceptability. However, patient satisfaction with long-acting injectable atypical antipsychotics has not been compared with that of oral atypical antipsychotics. Objective: The objective of the study was to identify differences in patient and caregiver satisfaction between long-acting injectable risperidone and oral atypical antipsychotics. Research design and methods: Forty-seven patients with schizophrenia, who were currently receiving treatment with long-acting injectable risperidone and their caregivers were surveyed using a semi-structured questionnaire that addressed their drug satisfaction and acceptability. Sixty-two patients currently taking oral atypical antipsychotics and their caregivers were surveyed for comparison. In the questionnaire, subjects were asked to indicate their satisfaction level on a 10-point visual analogue scale (VAS). Items to identify discomfort and side effects experienced were also included. Results: The VAS satisfaction score was significantly higher for patients receiving long-acting injectable risperidone than for those taking oral atypical antipsychotics (7.53 vs 6.87, P < 0.05). The overall VAS score was significantly higher for caregivers of both groups of patients than for the patients themselves (8.04 vs 7.16, P < 0.000). Conclusion: A new drug delivery system using long-acting injectable risperidone may offer better adherence in schizophrenia treatment, owing to higher levels of patient and caregiver satisfaction, and thereby result in improved treatment outcomes. Further studies in a strictly controlled setting are strongly needed because that present study was not strictly controlled and the duration of treatment of the injection group was relatively short.

Original languageEnglish
Pages (from-to)119-124
Number of pages6
JournalPrimary Care and Community Psychiatry
Issue number3
Publication statusPublished - 2005


  • Atypical
  • Depot
  • Long-acting injectable risperidone
  • Satisfaction

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health


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