Scalable Subsecond Synthesis of Drug Scaffolds via Aryllithium Intermediates by Numbered-up 3D-Printed Metal Microreactors

Ji Ho Kang, Gwang Noh Ahn, Heekwon Lee, Se Jun Yim, Santosh Lahore, Hyune Jea Lee, Heejin Kim, Ji Tae Kim, Dong Pyo Kim

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Continuous-flow microreactors enable ultrafast chemistry; however, their small capacity restricts industrial-level productivity of pharmaceutical compounds. In this work, scale-up subsecond synthesis of drug scaffolds was achieved via a 16 numbered-up printed metal microreactor (16N-PMR) assembly to render high productivity up to 20 g for 10 min operation. Initially, ultrafast synthetic chemistry of unstable lithiated intermediates in the halogen-lithium exchange reactions of three aryl halides and subsequent reactions with diverse electrophiles were carried out using a single microreactor (SMR). Larger production of the ultrafast synthesis was achieved by devising a monolithic module of 4 numbered-up 3D-printed metal microreactor (4N-PMR) that was integrated by laminating four SMRs and four bifurcation flow distributors in a compact manner. Eventually, the 16N-PMR system for the scalable subsecond synthesis of three drug scaffolds was assembled by stacking four monolithic modules of 4N-PMRs.

Original languageEnglish
Pages (from-to)43-50
Number of pages8
JournalACS Central Science
Volume8
Issue number1
DOIs
Publication statusPublished - 2022 Jan 26

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (NRF-2017R1A3B1023598). The fabrication of the 3D-printed microreactor was supported by the General Research Fund (17208218, 17208919, 17204020) of the Research Grants Council of Hong Kong and the Seed Fund for Basic Research (201910159047) of the University Research Committee (URC), the University of Hong Kong.

Publisher Copyright:
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ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering

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