Stilbene analogues have shown remarkable structural diversity constituting simple or tangled structures, which have attracted the synthetic as well as the medicinal chemistry communities. Schweinfurthins are a family of prenylated/geranylated/farnesylated stilbenes that are isolated from an African plant belonging to the Macaranga species. These compounds have displayed potency towards central nervous system, renal and breast cancer cell lines. Specifically, these compounds have been found to be potent and selective inhibitors of cell growth in the National Cancer Institute's 60 cell-line screen. In this review article, we described the isolation, synthesis, and biochemical properties of schweinfurthins.
Bibliographical noteFunding Information:
This work was supported by the National Research Foundation of Korea (NRF), grant funded by the Korea government (MSIT) (No. 2012M3A9C1053532 and 2015M3A6A4065734).
© The Royal Society of Chemistry 2018.
ASJC Scopus subject areas
- Chemical Engineering(all)