Seco-labdane diterpenoids from the leaves of Callicarpa nudiflora showing nitric oxide inhibitory activity

Xiaocong Sun; Feng Liu; Xueyuan Yang; Jinghan Wang; Bangjian Dong; Chunfeng Xie; Da Qing Jin; Jie Zhang; Dongho Lee; Yasushi Ohizumi; Jing Xu; Yuanqiang Guo

doi:10.1016/j.phytochem.2018.02.001

Seco-labdane diterpenoids from the leaves of Callicarpa nudiflora showing nitric oxide inhibitory activity

Xiaocong Sun, Feng Liu, Xueyuan Yang, Jinghan Wang, Bangjian Dong, Chunfeng Xie, Da Qing Jin, Jie Zhang, Dongho Lee, Yasushi Ohizumi, Jing Xu, Yuanqiang Guo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Nine previously undescribed seco-labdane diterpenoids, nudiflopenes A−I, were isolated from the leaves of Callicarpa nudiflora. Their structures were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analysis, and the absolute configurations of these compounds were established by the modified Mosher's method and experimental and calculated electronic circular dichroism spectra. Nudiflopenes A−I belong to the class of seco-labdane diterpenoids. All of the isolates showed inhibitory activities on lipopolysaccharide-induced nitric oxide (NO) production in murine microglial BV-2 cells. The possible mechanism of NO inhibition of some bioactive compounds was also investigated using molecular docking, which revealed interactions of bioactive compounds with the inducible nitric oxide synthase (iNOS) protein.

Original language	English
Pages (from-to)	31-41
Number of pages	11
Journal	Phytochemistry
Volume	149
DOIs	https://doi.org/10.1016/j.phytochem.2018.02.001
Publication status	Published - 2018 May

Bibliographical note

Funding Information:
This research was financially supported by the National Natural Science Foundation of China (Nos. 21642016 , U1703107 , and 21372125 ), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700 ), the State Key Laboratory of Medicinal Chemical Biology (No. 201602007 ), the Fundamental Research Funds for the Central Universities , and Hundred Young Academic Leaders Program of Nankai University .

Funding Information:
This research was financially supported by the National Natural Science Foundation of China (Nos. 21642016, U1703107, and 21372125), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700), the State Key Laboratory of Medicinal Chemical Biology (No. 201602007), the Fundamental Research Funds for the Central Universities, and Hundred Young Academic Leaders Program of Nankai University.

Publisher Copyright:
© 2018 Elsevier Ltd

Keywords

Callicarpa nudiflora
Molecular docking
NO inhibitory effects
Seco-labdane diterpenoids
Verbenaceae

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

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10.1016/j.phytochem.2018.02.001

Cite this

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title = "Seco-labdane diterpenoids from the leaves of Callicarpa nudiflora showing nitric oxide inhibitory activity",

abstract = "Nine previously undescribed seco-labdane diterpenoids, nudiflopenes A−I, were isolated from the leaves of Callicarpa nudiflora. Their structures were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analysis, and the absolute configurations of these compounds were established by the modified Mosher's method and experimental and calculated electronic circular dichroism spectra. Nudiflopenes A−I belong to the class of seco-labdane diterpenoids. All of the isolates showed inhibitory activities on lipopolysaccharide-induced nitric oxide (NO) production in murine microglial BV-2 cells. The possible mechanism of NO inhibition of some bioactive compounds was also investigated using molecular docking, which revealed interactions of bioactive compounds with the inducible nitric oxide synthase (iNOS) protein.",

keywords = "Callicarpa nudiflora, Molecular docking, NO inhibitory effects, Seco-labdane diterpenoids, Verbenaceae",

author = "Xiaocong Sun and Feng Liu and Xueyuan Yang and Jinghan Wang and Bangjian Dong and Chunfeng Xie and Jin, \{Da Qing\} and Jie Zhang and Dongho Lee and Yasushi Ohizumi and Jing Xu and Yuanqiang Guo",

note = "Funding Information: This research was financially supported by the National Natural Science Foundation of China (Nos. 21642016 , U1703107 , and 21372125 ), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700 ), the State Key Laboratory of Medicinal Chemical Biology (No. 201602007 ), the Fundamental Research Funds for the Central Universities , and Hundred Young Academic Leaders Program of Nankai University . Funding Information: This research was financially supported by the National Natural Science Foundation of China (Nos. 21642016, U1703107, and 21372125), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700), the State Key Laboratory of Medicinal Chemical Biology (No. 201602007), the Fundamental Research Funds for the Central Universities, and Hundred Young Academic Leaders Program of Nankai University. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2018",

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doi = "10.1016/j.phytochem.2018.02.001",

language = "English",

volume = "149",

pages = "31--41",

journal = "Phytochemistry",

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AU - Sun, Xiaocong

AU - Liu, Feng

AU - Yang, Xueyuan

AU - Wang, Jinghan

AU - Dong, Bangjian

AU - Xie, Chunfeng

AU - Jin, Da Qing

AU - Zhang, Jie

AU - Lee, Dongho

AU - Ohizumi, Yasushi

AU - Xu, Jing

AU - Guo, Yuanqiang

N1 - Funding Information: This research was financially supported by the National Natural Science Foundation of China (Nos. 21642016 , U1703107 , and 21372125 ), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700 ), the State Key Laboratory of Medicinal Chemical Biology (No. 201602007 ), the Fundamental Research Funds for the Central Universities , and Hundred Young Academic Leaders Program of Nankai University . Funding Information: This research was financially supported by the National Natural Science Foundation of China (Nos. 21642016, U1703107, and 21372125), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700), the State Key Laboratory of Medicinal Chemical Biology (No. 201602007), the Fundamental Research Funds for the Central Universities, and Hundred Young Academic Leaders Program of Nankai University. Publisher Copyright: © 2018 Elsevier Ltd

PY - 2018/5

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KW - NO inhibitory effects

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KW - Verbenaceae

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SN - 0031-9422

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JO - Phytochemistry

JF - Phytochemistry

ER -

Seco-labdane diterpenoids from the leaves of Callicarpa nudiflora showing nitric oxide inhibitory activity

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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