Secondary myeloid/natural killer cell acute leukemia following T-cell lymphoma

J. J. Lee; H. J. Kim; I. J. Chung; M. R. Park; D. W. Ryang; C. Choi

doi:10.3109/10428190109058005

Secondary myeloid/natural killer cell acute leukemia following T-cell lymphoma

J. J. Lee, H. J. Kim, I. J. Chung, M. R. Park, D. W. Ryang, C. Choi

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A 56-year-old woman was treated with combination chemotherapy and radiation therapy for peripheral T-cell lymphoma. Following complete remission for a period of 6 months, she returned again with marked leukocytosis. Leukemic cells were characterized by scanty cytoplasm with fine azurophilic granules, and were highly positive for myeloperoxidase and sudan black-B. Immunophenotypic analysis revealed that blast cells were positive for myeloid antigens (CD13, CD33), and natural killer (NK) cell antigen (CD56), but negative for T-cell antigens (CD2, CD5, CD7), B-cell antigens (CD19, CD20), CD34, and HLA-DR. The case was diagnosed as secondary myeloid/NK cell acute leukemia following non-Hodgkin's lymphoma. Despite aggressive chemotherapy against leukemia, she died of multiorgan failure 7 months following onset of leukemia. We present, to the best of our knowledge, the first published report of what seems to be a secondary myeloid/NK cell acute leukemia following T-cell lymphoma.

Original language	English
Pages (from-to)	457-460
Number of pages	4
Journal	Leukemia and Lymphoma
Volume	41
Issue number	3-4
DOIs	https://doi.org/10.3109/10428190109058005
Publication status	Published - 2001
Externally published	Yes

Keywords

Secondary myeloid/NK cell acute leukemia
T-cell lymphoma

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/10428190109058005

Cite this

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title = "Secondary myeloid/natural killer cell acute leukemia following T-cell lymphoma",

abstract = "A 56-year-old woman was treated with combination chemotherapy and radiation therapy for peripheral T-cell lymphoma. Following complete remission for a period of 6 months, she returned again with marked leukocytosis. Leukemic cells were characterized by scanty cytoplasm with fine azurophilic granules, and were highly positive for myeloperoxidase and sudan black-B. Immunophenotypic analysis revealed that blast cells were positive for myeloid antigens (CD13, CD33), and natural killer (NK) cell antigen (CD56), but negative for T-cell antigens (CD2, CD5, CD7), B-cell antigens (CD19, CD20), CD34, and HLA-DR. The case was diagnosed as secondary myeloid/NK cell acute leukemia following non-Hodgkin's lymphoma. Despite aggressive chemotherapy against leukemia, she died of multiorgan failure 7 months following onset of leukemia. We present, to the best of our knowledge, the first published report of what seems to be a secondary myeloid/NK cell acute leukemia following T-cell lymphoma.",

keywords = "Secondary myeloid/NK cell acute leukemia, T-cell lymphoma",

author = "Lee, {J. J.} and Kim, {H. J.} and Chung, {I. J.} and Park, {M. R.} and Ryang, {D. W.} and C. Choi",

year = "2001",

doi = "10.3109/10428190109058005",

language = "English",

volume = "41",

pages = "457--460",

journal = "Leukemia and Lymphoma",

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TY - JOUR

T1 - Secondary myeloid/natural killer cell acute leukemia following T-cell lymphoma

AU - Lee, J. J.

AU - Kim, H. J.

AU - Chung, I. J.

AU - Park, M. R.

AU - Ryang, D. W.

AU - Choi, C.

PY - 2001

Y1 - 2001

N2 - A 56-year-old woman was treated with combination chemotherapy and radiation therapy for peripheral T-cell lymphoma. Following complete remission for a period of 6 months, she returned again with marked leukocytosis. Leukemic cells were characterized by scanty cytoplasm with fine azurophilic granules, and were highly positive for myeloperoxidase and sudan black-B. Immunophenotypic analysis revealed that blast cells were positive for myeloid antigens (CD13, CD33), and natural killer (NK) cell antigen (CD56), but negative for T-cell antigens (CD2, CD5, CD7), B-cell antigens (CD19, CD20), CD34, and HLA-DR. The case was diagnosed as secondary myeloid/NK cell acute leukemia following non-Hodgkin's lymphoma. Despite aggressive chemotherapy against leukemia, she died of multiorgan failure 7 months following onset of leukemia. We present, to the best of our knowledge, the first published report of what seems to be a secondary myeloid/NK cell acute leukemia following T-cell lymphoma.

AB - A 56-year-old woman was treated with combination chemotherapy and radiation therapy for peripheral T-cell lymphoma. Following complete remission for a period of 6 months, she returned again with marked leukocytosis. Leukemic cells were characterized by scanty cytoplasm with fine azurophilic granules, and were highly positive for myeloperoxidase and sudan black-B. Immunophenotypic analysis revealed that blast cells were positive for myeloid antigens (CD13, CD33), and natural killer (NK) cell antigen (CD56), but negative for T-cell antigens (CD2, CD5, CD7), B-cell antigens (CD19, CD20), CD34, and HLA-DR. The case was diagnosed as secondary myeloid/NK cell acute leukemia following non-Hodgkin's lymphoma. Despite aggressive chemotherapy against leukemia, she died of multiorgan failure 7 months following onset of leukemia. We present, to the best of our knowledge, the first published report of what seems to be a secondary myeloid/NK cell acute leukemia following T-cell lymphoma.

KW - Secondary myeloid/NK cell acute leukemia

KW - T-cell lymphoma

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U2 - 10.3109/10428190109058005

DO - 10.3109/10428190109058005

M3 - Article

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AN - SCOPUS:0034991053

SN - 1042-8194

VL - 41

SP - 457

EP - 460

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

IS - 3-4

ER -

Secondary myeloid/natural killer cell acute leukemia following T-cell lymphoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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