Sedentary behaviors and light-intensity activities in relation to colorectal cancer risk

Nana Keum, Yin Cao, Hannah Oh, Stephanie A. Smith-Warner, John Orav, Kana Wu, Charles S. Fuchs, Eunyoung Cho, Edward L. Giovannucci

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

A recent meta-analysis found that sedentary behaviors are associated with an increased colorectal cancer (CRC) risk. Yet, the finding on TV viewing time, the most widely used surrogate of sedentary behaviors, was based on only two studies. Furthermore, light-intensity activities (e.g., standing and slow walking), non-sedentary by posture but close to sedentary behaviors by Metabolic Equivalent Task values, have not been investigated in relation to CRC risk. Thus, we prospectively analyzed the relationships based on 69,715 women from Nurses' Health Study (1992-2010) and 36,806 men from Health Professionals Follow-Up Study (1988 - 2010). Throughout follow-up, time spent on sedentary behaviors including sitting watching TV and on light-intensity activities were assessed repeatedly; incidence of CRC was ascertained. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models from each cohort. A total of 1,119 and 913 incident cases were documented from women and men, respectively. The multivariable HR comparing ≥ 21 versus < 7 hr/week of sitting watching TV was 1.21 (95% CI = 1.02 to 1.43, ptrend=.01) in women and 1.06 (95% CI = 0.84 to 1.34, ptrend=.93) in men. In women, those highly sedentary and physically less active had an approximately 41% elevated risk of CRC (95% CI = 1.03 to 1.92) compared with those less sedentary and physically more active. The other sedentary behaviors and light-intensity activities were not related to CRC risk in women or men. In conclusion, we found that prolonged sitting time watching TV was associated with an increased CRC risk in women but not in men.

Original languageEnglish
Pages (from-to)2109-2117
Number of pages9
JournalInternational Journal of Cancer
Volume138
Issue number9
DOIs
Publication statusPublished - 2016 May 1
Externally publishedYes

Bibliographical note

Funding Information:
NaNa Keum had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. We would like to thank the participants and staff of the HPFS and NHS for their valuable contributions as well as the 36 state cancer registries for their help. The authors assume full responsibility for analyses and interpretation of these data. This research was funded by the following federal grants: P01 CA87969, UM1 CA167552, P01 CA 55075, and UM1 CA186107. In addition, funding came from the Entertainment Industry Foundation’s National Colorectal Cancer Research Alliance. The funders had no role in: design or conduct of the study; collection, management, analysis or interpretation of the data; preparation, review or approval of the manuscript; or the decision to submit the manuscript for publication.

Funding Information:
NaNa Keum had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. We would like to thank the participants and staff of the HPFS and NHS for their valuable contributions as well as the 36 state cancer registries for their help. The authors assume full responsibility for analyses and interpretation of these data. This research was funded by the following federal grants: P01 CA87969, UM1 CA167552, P01 CA 55075, and UM1 CA186107. In addition, funding came from the Entertainment Industry Foundation?s National Colorectal Cancer Research Alliance. The funders had no role in: design or conduct of the study; collection, management, analysis or interpretation of the data; preparation, review or approval of the manuscript; or the decision to submit the manuscript for publication.

Publisher Copyright:
© 2015 UICC.

Keywords

  • TV watching
  • colorectal cancer
  • epidemiology
  • light-intensity activities
  • sedentary behaviors
  • sitting

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Sedentary behaviors and light-intensity activities in relation to colorectal cancer risk'. Together they form a unique fingerprint.

Cite this