See-through technology for biological tissue: 3-dimensional visualization of macromolecules

Eunsoo Lee, Hyun Jung Kim, Woong Sun

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)


Tissue clearing technology is currently one of the fastest growing fields in biomedical sciences. Tissue clearing techniques have become a powerful approach to understand further the structural information of intact biological tissues. Moreover, technological improvements in tissue clearing and optics allowed the visualization of neural network in the whole brain tissue with subcellular resolution. Here, we described an overview of various tissue-clearing techniques, with focus on the tissue-hydrogel mediated clearing methods, and discussed the main advantages and limitations of transparent tissue for clinical diagnosis.

Original languageEnglish
Pages (from-to)S15-S22
JournalInternational Neurourology Journal
Publication statusPublished - 2016 May 1

Bibliographical note

Funding Information:
This work was supported by the Brain Research Program through the National Research Foundation (NRF) funded by the Korean Ministry of Science, ICT and Future Planning (NRF-2015M3C7A1028790).

Publisher Copyright:
© 2016 Korean Continence Society.


  • Imaging
  • Immunolabeling
  • Molecular diagnosis
  • Neuroscience
  • Optical tissue clearing
  • Three-dimensional

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Urology


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