Selected SALM (Synaptic Adhesion-Like Molecule) family proteins regulate synapse formation

Won Mah, Jaewon Ko, Jungyong Nam, Kihoon Han, Woo Suk Chung, Eunjoon Kim

Research output: Contribution to journalArticlepeer-review

80 Citations (Scopus)


Synaptic cell adhesion molecules regulate various steps of synapse formation. Despite the great diversity of neuronal synapses, relatively few adhesion molecules with synaptogenic activity have been identified. Synaptic adhesion-like molecules (SALMs) are members of a family of cell adhesion molecules known to regulate neurite outgrowth and synapse maturation; however, the role of SALMs in synapse formation remains unknown. We found that expression of the SALM family proteins SALM3 and SALM5 in nonneural and neural cells induces both excitatory and inhibitory presynaptic differentiation in contacting axons. SALM3 and SALM5 proteins are enriched in synaptic fractions, and form strong (SALM3) or weak (SALM5) complexes with postsynaptic density-95 (PSD-95), an abundant postsynaptic scaffolding protein at excitatory synapses. Aggregation of SALM3, but not SALM5, on dendritic surfaces induces clustering of PSD-95.KnockdownofSALM5reduces thenumberand function of excitatory and inhibitory synapses. These results suggest that selected SALM family proteins regulate synapse formation, and that SALM3 and SALM5 may promote synapse formation through distinct mechanisms. Copyright

Original languageEnglish
Pages (from-to)5559-5568
Number of pages10
JournalJournal of Neuroscience
Issue number16
Publication statusPublished - 2010 Apr 21
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience


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