Selective human serum albumin sensor from the screening of a fluorescent rosamine library

Young Hoon Ahn; Jun Seok Lee; Young Tae Chang

doi:10.1021/cc800017h

Selective human serum albumin sensor from the screening of a fluorescent rosamine library

Young Hoon Ahn, Jun Seok Lee, Young Tae Chang

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

A fluorescent dye library approach for the development of a bioanalyte sensor was sought. The screening of a rosamine dye library against diverse macromolecules led to the discovery of a highly sensitive human serum albumin binder, G13, with ∼36-fold fluorescence intensity change. G13 showed a highly selective response to HSA over other macromolecules including albumins from other species. The potential use of G13 for the detection of HSA in biofluids is described.

Original language	English
Pages (from-to)	376-380
Number of pages	5
Journal	Journal of Combinatorial Chemistry
Volume	10
Issue number	3
DOIs	https://doi.org/10.1021/cc800017h
Publication status	Published - 2008 May
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)

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10.1021/cc800017h

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Selective human serum albumin sensor from the screening of a fluorescent rosamine library

Abstract

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