Selenium-Epoxy ‘Click’ Reaction and Se-Alkylation—Efficient Access to Organo-Selenium and Selenonium Compounds

Taejun Eom, Anzar Khan

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


This work establishes the ‘click’ nature of the base-catalyzed oxirane ring opening reaction by the selenolate nucleophile. The ‘click’-generated ß-hydroxy selenide can be alkylated to afford cationic selenium species. Hemolytic studies suggest that selenonium cations do not lyse red blood cells even at high concentrations. Overall, these results indicate the future applicability of the developed organo-selenium chemistry in the preparation of a new class of cationic materials based on the seleno-ether motif.

Original languageEnglish
Pages (from-to)827-836
Number of pages10
JournalChemistry (Switzerland)
Issue number4
Publication statusPublished - 2020 Dec

Bibliographical note

Funding Information:
Funding: This research was funded by National Research Foundation of Korea grant funded by the Korean government (MSIP) (NRF-18R1D1A1B07048527).

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.


  • organo-selenium
  • organo-selenonium
  • oxirane ring opening reaction
  • ‘click’ chemistry

ASJC Scopus subject areas

  • Electrochemistry
  • Inorganic Chemistry
  • Organic Chemistry
  • Chemistry (miscellaneous)


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