TY - JOUR
T1 - Selenoprotein gene nomenclature
AU - Regina, Brigelius Flohé
AU - Gladyshev, Vadim N.
AU - Arnér, Elias S.
AU - Berry, Marla J.
AU - Bruford, Elspeth A.
AU - Burk, Raymond F.
AU - Carlson, Bradley A.
AU - Castellano, Sergi
AU - Chavatte, Laurent
AU - Conrad, Marcus
AU - Copeland, Paul R.
AU - Diamond, Alan M.
AU - Driscoll, Donna M.
AU - Ferreiro, Ana
AU - Flohé, Leopold
AU - Green, Fiona R.
AU - Guigó, Roderic
AU - Handy, Diane E.
AU - Hatfield, Dolph L.
AU - Hesketh, John
AU - Hoffmann, Peter R.
AU - Holmgren, Arne
AU - Hondal, Robert J.
AU - Howard, Michael T.
AU - Huang, Kaixun
AU - Kim, Hwa Young
AU - Kim, Ick Young
AU - Köhrle, Josef
AU - Krol, Alain
AU - Kryukov, Gregory V.
AU - Lee, Byeong Jae
AU - Lee, Byung Cheon
AU - Lei, Xin Gen
AU - Liu, Qiong
AU - Lescure, Alain
AU - Lobanov, Alexei V.
AU - Loscalzo, Joseph
AU - Maiorino, Matilde
AU - Mariotti, Marco
AU - Prabhu, K. Sandeep
AU - Rayman, Margaret P.
AU - Rozovsky, Sharon
AU - Salinas, Gustavo
AU - Schmidt, Edward E.
AU - Schomburg, Lutz
AU - Schweizer, Ulrich
AU - Simonović, Miljan
AU - Sunde, Roger A.
AU - Tsuji, Petra A.
AU - Tweedie, Susan
AU - Ursini, F. Fulvio
AU - Whanger, Philip D.
AU - Zhang, Yan
PY - 2016/11/11
Y1 - 2016/11/11
N2 - The human genome contains 25 genes coding for selenocysteine- containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, and GPX6 (glutathione peroxidases), DIO1, DIO2, and DIO3 (iodothyronine deiodinases), MSRB1 (methionine sulfoxide reductase B1), and SEPHS2 (selenophosphate synthetase 2). Selenoproteins without known functions have traditionally been denoted by SEL or SEP symbols. However, these symbols are sometimes ambiguous and conflict with the approved nomenclature for several other genes. Therefore, there is a need to implement a rational and coherent nomenclature system for selenoprotein- encoding genes. Our solution is to use the root symbol SELENO followed by a letter. This nomenclature applies to SELENOF (selenoprotein F, the 15-kDa selenoprotein, SEP15), SELENOH (selenoprotein H, SELH, C11orf31), SELENOI (selenoprotein I, SELI, EPT1), SELENOK (selenoprotein K, SELK), SELENOM (selenoprotein M, SELM), SELENON (selenoprotein N, SEPN1, SELN), SELENOO (selenoprotein O, SELO), SELENOP (selenoprotein P, SeP, SEPP1, SELP), SELENOS (selenoprotein S, SELS, SEPS1, VIMP),SELENOT(selenoprotein T, SELT),SELENOV(selenoprotein V, SELV), andSELENOW(selenoprotein W, SELW, SEPW1). This system, approved by the HUGO Gene Nomenclature Committee, also resolves conflicting, missing, and ambiguous designations for selenoprotein genes and is applicable to selenoproteins across vertebrates.
AB - The human genome contains 25 genes coding for selenocysteine- containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, and GPX6 (glutathione peroxidases), DIO1, DIO2, and DIO3 (iodothyronine deiodinases), MSRB1 (methionine sulfoxide reductase B1), and SEPHS2 (selenophosphate synthetase 2). Selenoproteins without known functions have traditionally been denoted by SEL or SEP symbols. However, these symbols are sometimes ambiguous and conflict with the approved nomenclature for several other genes. Therefore, there is a need to implement a rational and coherent nomenclature system for selenoprotein- encoding genes. Our solution is to use the root symbol SELENO followed by a letter. This nomenclature applies to SELENOF (selenoprotein F, the 15-kDa selenoprotein, SEP15), SELENOH (selenoprotein H, SELH, C11orf31), SELENOI (selenoprotein I, SELI, EPT1), SELENOK (selenoprotein K, SELK), SELENOM (selenoprotein M, SELM), SELENON (selenoprotein N, SEPN1, SELN), SELENOO (selenoprotein O, SELO), SELENOP (selenoprotein P, SeP, SEPP1, SELP), SELENOS (selenoprotein S, SELS, SEPS1, VIMP),SELENOT(selenoprotein T, SELT),SELENOV(selenoprotein V, SELV), andSELENOW(selenoprotein W, SELW, SEPW1). This system, approved by the HUGO Gene Nomenclature Committee, also resolves conflicting, missing, and ambiguous designations for selenoprotein genes and is applicable to selenoproteins across vertebrates.
UR - http://www.scopus.com/inward/record.url?scp=84995487883&partnerID=8YFLogxK
U2 - 10.1074/jbc.M116.756155
DO - 10.1074/jbc.M116.756155
M3 - Article
C2 - 27645994
AN - SCOPUS:84995487883
SN - 0021-9258
VL - 291
SP - 24036
EP - 24040
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 46
ER -