Self-aggregates of deoxycholic acid-modified chitosan as a novel carrier of adriamycin

K. Y. Lee; J. H. Kim; I. C. Kwon; S. Y. Jeong

doi:10.1007/s003960000389

Self-aggregates of deoxycholic acid-modified chitosan as a novel carrier of adriamycin

K. Y. Lee, J. H. Kim, I. C. Kwon, S. Y. Jeong

Research output: Contribution to journal › Article › peer-review

110 Citations (Scopus)

Abstract

A novel and simple method for delivery of adriamycin (ADR) was developed using self-aggregates of deoxycholic acid-modified chitosan. Deoxycholic acid was covalently conjugated to chitosan via EDC-mediated reaction to generate self-aggregated chitosan nanoparticles. ADR was physically entrapped inside the self-aggregates and the characteristics of ADR-loaded chitosan self-aggregates were analyzed by dynamic light scattering, fluorescence spectroscopy, and atomic force microscopy (AFM). The maximum amount of entrapped ADR reached 16.5 wt% of chitosan self-aggregates, suggesting a loading efficiency of 49.6 wt%. The size of ADR-loaded self-aggregates increased with increasing the loading content of ADR. AFM images showed spherical shape of ADR-loaded self-aggregates, and ADR was slowly released from chitosan self-aggregates in PBS solution (pH 7.2).

Original language	English
Pages (from-to)	1216-1219
Number of pages	4
Journal	Colloid and Polymer Science
Volume	278
Issue number	12
DOIs	https://doi.org/10.1007/s003960000389
Publication status	Published - 2000

Keywords

Adriamycin
Chitosan
Deoxycholic acid
Nanoparticle
Self-aggregate

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Polymers and Plastics
Colloid and Surface Chemistry
Materials Chemistry

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10.1007/s003960000389

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title = "Self-aggregates of deoxycholic acid-modified chitosan as a novel carrier of adriamycin",

abstract = "A novel and simple method for delivery of adriamycin (ADR) was developed using self-aggregates of deoxycholic acid-modified chitosan. Deoxycholic acid was covalently conjugated to chitosan via EDC-mediated reaction to generate self-aggregated chitosan nanoparticles. ADR was physically entrapped inside the self-aggregates and the characteristics of ADR-loaded chitosan self-aggregates were analyzed by dynamic light scattering, fluorescence spectroscopy, and atomic force microscopy (AFM). The maximum amount of entrapped ADR reached 16.5 wt% of chitosan self-aggregates, suggesting a loading efficiency of 49.6 wt%. The size of ADR-loaded self-aggregates increased with increasing the loading content of ADR. AFM images showed spherical shape of ADR-loaded self-aggregates, and ADR was slowly released from chitosan self-aggregates in PBS solution (pH 7.2).",

keywords = "Adriamycin, Chitosan, Deoxycholic acid, Nanoparticle, Self-aggregate",

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year = "2000",

doi = "10.1007/s003960000389",

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T1 - Self-aggregates of deoxycholic acid-modified chitosan as a novel carrier of adriamycin

AU - Lee, K. Y.

AU - Kim, J. H.

AU - Kwon, I. C.

AU - Jeong, S. Y.

PY - 2000

Y1 - 2000

N2 - A novel and simple method for delivery of adriamycin (ADR) was developed using self-aggregates of deoxycholic acid-modified chitosan. Deoxycholic acid was covalently conjugated to chitosan via EDC-mediated reaction to generate self-aggregated chitosan nanoparticles. ADR was physically entrapped inside the self-aggregates and the characteristics of ADR-loaded chitosan self-aggregates were analyzed by dynamic light scattering, fluorescence spectroscopy, and atomic force microscopy (AFM). The maximum amount of entrapped ADR reached 16.5 wt% of chitosan self-aggregates, suggesting a loading efficiency of 49.6 wt%. The size of ADR-loaded self-aggregates increased with increasing the loading content of ADR. AFM images showed spherical shape of ADR-loaded self-aggregates, and ADR was slowly released from chitosan self-aggregates in PBS solution (pH 7.2).

AB - A novel and simple method for delivery of adriamycin (ADR) was developed using self-aggregates of deoxycholic acid-modified chitosan. Deoxycholic acid was covalently conjugated to chitosan via EDC-mediated reaction to generate self-aggregated chitosan nanoparticles. ADR was physically entrapped inside the self-aggregates and the characteristics of ADR-loaded chitosan self-aggregates were analyzed by dynamic light scattering, fluorescence spectroscopy, and atomic force microscopy (AFM). The maximum amount of entrapped ADR reached 16.5 wt% of chitosan self-aggregates, suggesting a loading efficiency of 49.6 wt%. The size of ADR-loaded self-aggregates increased with increasing the loading content of ADR. AFM images showed spherical shape of ADR-loaded self-aggregates, and ADR was slowly released from chitosan self-aggregates in PBS solution (pH 7.2).

KW - Adriamycin

KW - Chitosan

KW - Deoxycholic acid

KW - Nanoparticle

KW - Self-aggregate

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ER -

Self-aggregates of deoxycholic acid-modified chitosan as a novel carrier of adriamycin

Abstract

Keywords

ASJC Scopus subject areas

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