Self-assembled nanoparticles based on linoleic-acid modified carboxymethyl-chitosan as carrier of adriamycin (ADR)

Chenguang Liu; Wenwen Fan; Xiguang Chen; Chengsheng Liu; Xianghong Meng; Hyun Jin Park

doi:10.1016/j.cap.2006.11.031

Self-assembled nanoparticles based on linoleic-acid modified carboxymethyl-chitosan as carrier of adriamycin (ADR)

Chenguang Liu, Wenwen Fan, Xiguang Chen, Chengsheng Liu, Xianghong Meng, Hyun Jin Park

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Linoleic-acid (LA) is covalently conjugated to carboxymethyl-chitosan via a 1-ethyl-3-(3-dimethylaminopropyyl)-carbodiimide-mediated (EDC-mediated) reaction to generate self-aggregated chitosan nanoparticles by sonication. The average diameter of the particles is 417.8 nm, with a size range from 222.8 nm to 1028 nm. Adriamycin (ADR) can be physically entrapped into the self-aggregates. The drug loading experiments indicate that the loading capacity and efficiency increase with increasing concentration of ADR. ADR is slowly released from chitosan self-aggregates for about 3 days. Furthermore, the effects of drug controlled release become more obvious on increasing the pH value.

Original language	English
Pages (from-to)	e125-e129
Journal	Current Applied Physics
Volume	7
Issue number	SUPPL.1
DOIs	https://doi.org/10.1016/j.cap.2006.11.031
Publication status	Published - 2007 Apr

Keywords

Adriamycin
Carboxymethyl-chitosan
Linoleic-acid
Nanoparticles

ASJC Scopus subject areas

Materials Science(all)
Physics and Astronomy(all)

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10.1016/j.cap.2006.11.031

Cite this

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title = "Self-assembled nanoparticles based on linoleic-acid modified carboxymethyl-chitosan as carrier of adriamycin (ADR)",

abstract = "Linoleic-acid (LA) is covalently conjugated to carboxymethyl-chitosan via a 1-ethyl-3-(3-dimethylaminopropyyl)-carbodiimide-mediated (EDC-mediated) reaction to generate self-aggregated chitosan nanoparticles by sonication. The average diameter of the particles is 417.8 nm, with a size range from 222.8 nm to 1028 nm. Adriamycin (ADR) can be physically entrapped into the self-aggregates. The drug loading experiments indicate that the loading capacity and efficiency increase with increasing concentration of ADR. ADR is slowly released from chitosan self-aggregates for about 3 days. Furthermore, the effects of drug controlled release become more obvious on increasing the pH value.",

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author = "Chenguang Liu and Wenwen Fan and Xiguang Chen and Chengsheng Liu and Xianghong Meng and Park, {Hyun Jin}",

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AU - Liu, Chenguang

AU - Fan, Wenwen

AU - Chen, Xiguang

AU - Liu, Chengsheng

AU - Meng, Xianghong

AU - Park, Hyun Jin

PY - 2007/4

Y1 - 2007/4

N2 - Linoleic-acid (LA) is covalently conjugated to carboxymethyl-chitosan via a 1-ethyl-3-(3-dimethylaminopropyyl)-carbodiimide-mediated (EDC-mediated) reaction to generate self-aggregated chitosan nanoparticles by sonication. The average diameter of the particles is 417.8 nm, with a size range from 222.8 nm to 1028 nm. Adriamycin (ADR) can be physically entrapped into the self-aggregates. The drug loading experiments indicate that the loading capacity and efficiency increase with increasing concentration of ADR. ADR is slowly released from chitosan self-aggregates for about 3 days. Furthermore, the effects of drug controlled release become more obvious on increasing the pH value.

AB - Linoleic-acid (LA) is covalently conjugated to carboxymethyl-chitosan via a 1-ethyl-3-(3-dimethylaminopropyyl)-carbodiimide-mediated (EDC-mediated) reaction to generate self-aggregated chitosan nanoparticles by sonication. The average diameter of the particles is 417.8 nm, with a size range from 222.8 nm to 1028 nm. Adriamycin (ADR) can be physically entrapped into the self-aggregates. The drug loading experiments indicate that the loading capacity and efficiency increase with increasing concentration of ADR. ADR is slowly released from chitosan self-aggregates for about 3 days. Furthermore, the effects of drug controlled release become more obvious on increasing the pH value.

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KW - Carboxymethyl-chitosan

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KW - Nanoparticles

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Self-assembled nanoparticles based on linoleic-acid modified carboxymethyl-chitosan as carrier of adriamycin (ADR)

Abstract

Keywords

ASJC Scopus subject areas

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