Self-assembled nanoparticles based on linoleic-acid modified carboxymethyl-chitosan as carrier of adriamycin (ADR)

Chenguang Liu; Wenwen Fan; Xiguang Chen; Chengsheng Liu; Xianghong Meng; Hyun Jin Park

doi:10.1016/j.cap.2006.11.031

Self-assembled nanoparticles based on linoleic-acid modified carboxymethyl-chitosan as carrier of adriamycin (ADR)

Chenguang Liu
, Wenwen Fan
, Xiguang Chen
, Chengsheng Liu
, Xianghong Meng
, Hyun Jin Park

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Linoleic-acid (LA) is covalently conjugated to carboxymethyl-chitosan via a 1-ethyl-3-(3-dimethylaminopropyyl)-carbodiimide-mediated (EDC-mediated) reaction to generate self-aggregated chitosan nanoparticles by sonication. The average diameter of the particles is 417.8 nm, with a size range from 222.8 nm to 1028 nm. Adriamycin (ADR) can be physically entrapped into the self-aggregates. The drug loading experiments indicate that the loading capacity and efficiency increase with increasing concentration of ADR. ADR is slowly released from chitosan self-aggregates for about 3 days. Furthermore, the effects of drug controlled release become more obvious on increasing the pH value.

Original language	English
Pages (from-to)	e125-e129
Journal	Current Applied Physics
Volume	7
Issue number	SUPPL.1
DOIs	https://doi.org/10.1016/j.cap.2006.11.031
Publication status	Published - 2007 Apr

Keywords

Adriamycin
Carboxymethyl-chitosan
Linoleic-acid
Nanoparticles

ASJC Scopus subject areas

General Materials Science
General Physics and Astronomy

Access to Document

10.1016/j.cap.2006.11.031

Cite this

@article{4886948dd4534b37a3de2106cd29cd4b,

title = "Self-assembled nanoparticles based on linoleic-acid modified carboxymethyl-chitosan as carrier of adriamycin (ADR)",

abstract = "Linoleic-acid (LA) is covalently conjugated to carboxymethyl-chitosan via a 1-ethyl-3-(3-dimethylaminopropyyl)-carbodiimide-mediated (EDC-mediated) reaction to generate self-aggregated chitosan nanoparticles by sonication. The average diameter of the particles is 417.8 nm, with a size range from 222.8 nm to 1028 nm. Adriamycin (ADR) can be physically entrapped into the self-aggregates. The drug loading experiments indicate that the loading capacity and efficiency increase with increasing concentration of ADR. ADR is slowly released from chitosan self-aggregates for about 3 days. Furthermore, the effects of drug controlled release become more obvious on increasing the pH value.",

keywords = "Adriamycin, Carboxymethyl-chitosan, Linoleic-acid, Nanoparticles",

author = "Chenguang Liu and Wenwen Fan and Xiguang Chen and Chengsheng Liu and Xianghong Meng and Park, \{Hyun Jin\}",

year = "2007",

month = apr,

doi = "10.1016/j.cap.2006.11.031",

language = "English",

volume = "7",

pages = "e125--e129",

journal = "Current Applied Physics",

issn = "1567-1739",

publisher = "Elsevier B.V.",

number = "SUPPL.1",

}

TY - JOUR

T1 - Self-assembled nanoparticles based on linoleic-acid modified carboxymethyl-chitosan as carrier of adriamycin (ADR)

AU - Liu, Chenguang

AU - Fan, Wenwen

AU - Chen, Xiguang

AU - Liu, Chengsheng

AU - Meng, Xianghong

AU - Park, Hyun Jin

PY - 2007/4

Y1 - 2007/4

N2 - Linoleic-acid (LA) is covalently conjugated to carboxymethyl-chitosan via a 1-ethyl-3-(3-dimethylaminopropyyl)-carbodiimide-mediated (EDC-mediated) reaction to generate self-aggregated chitosan nanoparticles by sonication. The average diameter of the particles is 417.8 nm, with a size range from 222.8 nm to 1028 nm. Adriamycin (ADR) can be physically entrapped into the self-aggregates. The drug loading experiments indicate that the loading capacity and efficiency increase with increasing concentration of ADR. ADR is slowly released from chitosan self-aggregates for about 3 days. Furthermore, the effects of drug controlled release become more obvious on increasing the pH value.

AB - Linoleic-acid (LA) is covalently conjugated to carboxymethyl-chitosan via a 1-ethyl-3-(3-dimethylaminopropyyl)-carbodiimide-mediated (EDC-mediated) reaction to generate self-aggregated chitosan nanoparticles by sonication. The average diameter of the particles is 417.8 nm, with a size range from 222.8 nm to 1028 nm. Adriamycin (ADR) can be physically entrapped into the self-aggregates. The drug loading experiments indicate that the loading capacity and efficiency increase with increasing concentration of ADR. ADR is slowly released from chitosan self-aggregates for about 3 days. Furthermore, the effects of drug controlled release become more obvious on increasing the pH value.

KW - Adriamycin

KW - Carboxymethyl-chitosan

KW - Linoleic-acid

KW - Nanoparticles

UR - https://www.scopus.com/pages/publications/33847111064

UR - https://www.scopus.com/pages/publications/33847111064#tab=citedBy

U2 - 10.1016/j.cap.2006.11.031

DO - 10.1016/j.cap.2006.11.031

M3 - Article

AN - SCOPUS:33847111064

SN - 1567-1739

VL - 7

SP - e125-e129

JO - Current Applied Physics

JF - Current Applied Physics

IS - SUPPL.1

ER -

Self-assembled nanoparticles based on linoleic-acid modified carboxymethyl-chitosan as carrier of adriamycin (ADR)

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this