Self-assembled nanoparticles based on linoleic-acid modified chitosan: Stability and adsorption of trypsin

Chen Guang Liu, Xi Guang Chen, Hyun Jin Park

Research output: Contribution to journalArticlepeer-review

84 Citations (Scopus)


The hydrogel nanoparticles can be prepared using linoleic modified chitosan following sonication. The morphology and size distribution of nanoparticles were determined by AFM and photocorrelation spectroscopy, respectively. The effects of environment factors on particle size and adsorption of trypsin (TR) were also analyzed. The LA-chitosan nanoparticles were in the range of 200-600 nm with satisfactory structural integrity. The particle size slightly increased with an increase in concentration. In high ionic strength solution the particle size decreased, compared to salt-free solution, on the other hand, the particles size increases as urea concentration increased. The particle size was found to be larger in acidic solution than in neutral and alkaline solution. Environment factors (e.g. pH, concentration of urea or NaCl) can affect TR loading on the nanoparticle. The thermal stability of TR loading on nanoparticles was significantly improved compared to free TR.

Original languageEnglish
Pages (from-to)293-298
Number of pages6
JournalCarbohydrate Polymers
Issue number3
Publication statusPublished - 2005 Dec 1

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Health 21 R & D Project (A050376), Ministry of Health & Welfare, Republic of Korea.


  • Adsorption
  • Hydrophobically modified chitosan
  • Nanoparticles
  • Trypsin

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry


Dive into the research topics of 'Self-assembled nanoparticles based on linoleic-acid modified chitosan: Stability and adsorption of trypsin'. Together they form a unique fingerprint.

Cite this